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Arene Ruthenium Compounds as Anticancer Drugs. Arene Ruthenium Complexes as Anticancer Drugs. Current used drug - Platinum based complexes Ruthenium complexes ( Ru ) - Arene Ruthenium Complexes. Platinum based drugs .
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Arene Ruthenium Complexes as Anticancer Drugs • Current used drug - Platinum based complexes • Ruthenium complexes (Ru) - Arene Ruthenium Complexes
Drawbacks of Platinum complexes • Limited range of activity - testicular and ovarian cancer cells • High toxicity - side effects (e.g. alopecia) • Drug resistance
Ruthenium Complexes Based on Platinum Drugs • Same cytotoxicity • More selectivity - similar property as Iron (Fe) - overexpression of transferrin receptors in cancer cells
Active against secondary tumour cells Active against primary tumour cells
Attractive Properties of ARC • Right ligand exchange kinetics (10-3 to 10-2 s-1) • High selectivity - Ru can mimic Fe - the reactivity depends on pH
Attractive Properties of ARC - adjustable ligands • Low general toxicity • Lessdrugresistance
Attractive Properties of ARC • Amphiphilic properties - high cellular uptake - good water solubility • Synthetic diversity of areneligandtargetedtherapy
Further Applications: Synergistic Effect
Further Applications: Photodynamic Therapy release of NO
Conclusion • Arene Ruthenium Complexes- PROMISING ANTICANCER DRUGS • FURTHER STUDY IS NEEDED - X-Ray Absorption Spectroscopy - X-Ray Fluorescence Mapping DESIGN ENHANCED ANTICANCER DRUGS
References 1. Suss-Fink G., 2010. Arene Ruthenium Complexes as Anticancer Agents.The Royal Society of Chemistry. 39, 1673-88 2. Levina, et al., 2009. Recent Developments in Ruthenium Anticancer Agents. The Royal Society of Chemistry. 1, 458-470.