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pharmacogenomic Anoud abdelaziz
introduction Each of us responds differently to our environment, to the foods we eat, and to the drugs we take. The way we respond to drugs may mean that a drug that is effective for one person may be less effective for another, or that a drug that is safe for one person may be dangerous for another person—even at thesame dosage.
What is pharmacogenomic? Pharmacogenomics is the study of how genes affect a person’s response to drugs. It is the science that examines the inherited variations in genes that dictate drug response and explore the ways in which these variations can be used to predict whether a patient will have a good response to a drug, a bad response to a drug or no response at all.
pharmacogenomics The term comes from the words pharmacology ( the science of drugs ) and genomics ( the study of genes and their function ) and is thus the intersection of pharmaceuticals and genetics.
pharmacogenomic Researchers in this field study genes that produce drug metabolizing-enzyme in the body. Many drugs are altered by the body by metabolizing them using enzymes. In some cases, an active drug is made inactive or less active through metabolism and vice versa.
pharmacogenomic There are multiple contributed factors to such variation in drug response such as gender, age, body mass, diet, co-medication ( the presence of other drugs ) or of a particular disease and exposure to certain chemicals or toxins.
pharmacogenomic Utilizing an individual's genetic profile in prescribing medications for various diseases will prevent unwanted side effects and allow drug to work more efficiently.
Some of the anticipated benefits of pharmacogenomics Making better medication choices. Better Vaccines. Decrease in the Overall Cost of Health Care.
some of the barriers to usingpharmacogenomics The field of pharmacogenomics is still in its early stages. It's possible that millions of genetic variations may exist, and identifying them all could take many years — if it's even possible. In addition, how you respond to a medication may not be determined by just one gene but rather by many genes interacting with each other. Combing through this complicated genetic map is expensive and time-consuming.
pharmacogenomic Although the use of pharmacogenomic is currently quite limited but new approaches are under study in clinical trials. In the future, this field will allow the development of tailored drugs to treat a wide range of health problems, including cardiovascular disease, Alzheimer disease, cancer, HIV/AIDS and Asthma.