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Cycle 7 – Sleep, and Memory formation

Cycle 7 – Sleep, and Memory formation. Memory Consolidation. Trace Reactivation. Slow wave Sleep. Cycle 7 – Sleep, and Memory formation. Memory Consolidation. At the time of encoding, memories are susceptible to disruption. With time, they become robust to interference

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Cycle 7 – Sleep, and Memory formation

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  1. Cycle 7 – Sleep, and Memory formation Memory Consolidation Trace Reactivation Slow wave Sleep

  2. Cycle 7 – Sleep, and Memory formation Memory Consolidation At the time of encoding, memories are susceptible to disruption. With time, they become robust to interference (Mueller and Pilzecker, 1900) Cerebral trauma leads to a greater loss of recent than remote memories (Ribot, 1882)

  3. Cycle 7 – Sleep, and Memory formation SLEEP Non-REM REM Stages 1 2 3 4 Spindles Slow wave,delta

  4. Cycle 7 – Sleep, and Memory formation

  5. Cycle 7 – Sleep, and Memory formation Slow-wave sleep Slow waves (a.k.a up/down states) Neuroscience 137 (2006) 1087–1106 GROUPING OF BRAIN RHYTHMS IN CORTICOTHALAMIC SYSTEMS M. STERIADE* Laboratory of Neurophysiology, Laval University, Faculty of Medicine, Quebec, Canada G1K 7P4

  6. Cycle 7 – Sleep, and Memory formation Is there evidence for trace replay theory? … when neural activity patterns seen during a task are ‘replayed’ during subsequent periods of inactivity

  7. Cycle 7 – Sleep, and Memory formation Reactivation • In rats, hippocampal activity patterns during behavior are related to patterns during subsequent periods of inactivity(Pavlides and Winson, 1989; Wilson and McNaughton, 1994), • specifically, in hippocampal oscillations (Kudrimoti et al., 1999) • demonstrated to co-occur with slow-waves (Sirota et al., 2003; Battaglia et al., 2004) • seen in the hippocampus and neocortex of rats (Qin et al., 1997; Ribeiro et al., 2004; Ji and Wilson, 2007) • seen in non-human primate, in multiple ‘disconnected’ sites, coordinated across hemispheres. (Hoffman and McNaughton, 2002) • seen in other structures, maybe under other names (Arieli, Yuste/MacLean, Dan)

  8. Cycle 7 – Sleep, and Memory formation Slow-waves enhance declarative memory • Marshall ’06 stimulated humans at SW freq during SWS, and found selective enhancement of memory for word pairs. • Selective for slow waves (not theta stim) • Selective for word association memory (not procedural finger-tapping task) *** One example of how oscillations are more than epiphenomenal.

  9. The upshot of up states in neocortex: From slow oscillations to memory formation Memory Consolidation Trace Reactivation Slow wave Sleep

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