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Pancreatic Hormones

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Pancreatic Hormones

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    1. Pancreatic Hormones Glucagon Insulin

    2. Pancreas Histology

    3. Pancreas

    4. Islets of Langerhan (Pancreatic Islets)

    5. Pancreatic Hormones, Insulin & Glucagon Regulate Metabolism

    10. Insulin Stimulates Cellular Glucose Uptake

    11. Glucagon and Insulin

    12. Action of Insulin on Adipose Tissue Stimulates glucose uptake Stimulates glycolysis Stimulates lipogenesis Inhibits lipolysis and ketogenesis

    13. Actions of Glucagon on the Liver Stimulates glycogenolysis Stimulates gluconeogenesis Inhibits glycolysis Stimulates lipolysis and ketogenesis

    17. Actions of Insulin on the Liver Stimulates glucose uptake Stimulates glycogenesis Stimulates glycolysis Stimulates HMP shunt activity Inhibits glycogenolysis Inhibits gluconeogenesis Stimulates lipogenesis Inhibits lipolysis Stimulates cholesterol synthesis Increases VLD lipoprotein Increases potassium and phosphate uptake

    18. Actions of Insulin on Muscle Stimulates glucose uptake Stimulates glycogenesis Stimulates glycolysis Inhibits glycogenolysis Inhibits FFA uptake and oxidation Stimulates proteogenesis Inhibits proteolysis Stimulates uptake of potassium, phosphate and magnesium Increases blood flow

    21. Normal

    22. Type 1 Diabetes Mellitus

    23. Diabetes Mellitus This is a disease caused by elevated glucose levels 2 Types of diabetes: Type I diabetes (10% of cases) Type II diabetes (90% of cases)

    24. Type I Diabetes (10% of cases) Develops suddenly, usually before age 15 Caused by inadequate production of insulin because T cell-mediated autoimmune response destroys beta cells Controlled by insulin injections

    25. Type II diabetes (90% of cases) Usually occurs after age 40 and in obese individuals Insulin levels are normal or elevated but there is either a decrease in number of insulin receptors or the cells cannot take it up. Controlled by dietary changes and regular exercise

    26. Glucose homeostasis

    27. Type 2 diabetes: patophysiology

    28. FOOD

    29. Prevention of obesity

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