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ProKnee Professional Protection. Ravi Chacko CEO Chase McCaleb CFO Walker Plash CMO Perry Yin CTO George Zhou CRO. Problem | Market | Company | Product| Business Plan | Development| Finances. ACL Injury. 100,000 -200,000 rupturs per year 1
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ProKneeProfessional Protection Ravi Chacko CEO Chase McCaleb CFO Walker Plash CMO Perry Yin CTO George Zhou CRO
Problem | Market | Company | Product| Business Plan | Development| Finances ACL Injury • 100,000 -200,000 rupturs per year1 • 60,000-75,000 ACL reconstructions are performed annually2 • Surgery > $10,000; Rehab >$10,000; Time ~ 1 year 3 • Lifelong effects (i.e. Patellofemoral Syndrome, Osteoarthritis) • No currently available options for general risk assessment aimed towards prevention 1. Mayo Clinic Online 2. JD Hubbell, MD; E Schwartz, MD; http://emedicine.medscape.com/article/89442-overview 3. WebMD
Problem | Market | Company | Product| Business Plan | Development| Finances Market • CDC estimates 7.2mil high school athletes in the US1 • NCAA comprises 400,000+ athletes • 700+ men’s and 500+ women’s soccer teams total • FIFA estimates 265mil people play soccer worldwide2 • In soccer, 70% of all ACL injuries are non-contact3 • UEFA’s top 25 teams have an operating income of over $1 billion and revenue of $7 billion in 20094 CDC: MMWR; September 29, 2006 / 55(38);1037-1040; http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5538a1.htm A Junge; J Dvorak; Br J Sports Med 2007 41: i3-i7; doi: 10.1136/bjsm.2007.036020 Katharina Grimm, MD; Holly Silver, PT; Bert Mandelbaum, MD; Health and Fitness for the Female Football Player ; http://www.fifa.com/mm/document/afdeveloping/medical/ffb_gesamt_e_20035.pdf http://www.forbes.com/lists/2009/34/soccer-values-09_Soccer-Team-Valuations_Rank.html
Problem | Market | Company | Product| Business Plan | Development| Finances Mechanical and Physiological Modeling Wearable during athletic movements Massive database Small scale data collection Mechanical or Physiological Modeling Laboratory based movements The ProKnee Advantage
Problem | Market | Company | Product| Business Plan | Development| Finances Design
Problem | Market | Company | Product| Business Plan | Development| Finances Design – Insole Attachment • Gyroscope/Accelerometer • Work together to give position to calculate ankle angle • Wire • Connects to knee straps for power and to relay data • Force Sensors • Force summed to find moment at knee at impact • Determines time • of impact
Problem | Market | Company | Product| Business Plan | Development| Finances Design – Knee Straps • Gyroscope/Accelerometer • Work together to give position to calculate flexion angle and medial motion angle • EMG (VL-ST) • Measures muscle activation • Wire • Connects to hip pack for power electronics and relay data
Problem | Market | Company | Product| Business Plan | Development| Finances Design – Hip Pack • Battery (9V) • Power electronics in unit • USB Memory (1 GB) • Stores data for use with software later • Gyroscope/Accelerometer • Work together to give position and angle of torso • Wire • Connects to knee straps to power electronics and receive information
Problem | Market | Company | Product| Business Plan | Development| Finances Design
Problem | Market | Company | Product| Business Plan | Development| Finances Business Model
Problem | Market | Company | Product| Business Plan | Development| Finances Business Model (cont.)
Problem | Market | Company | Product| Business Plan | Development| Finances Phase I Phase II Phase III Phase IV Months: 0 6 18 30 • Phase I • Prototype 1 – Accurately model knee movement: • Test 1: Differentiate between people • Test 2: Differentiate between motions of an individual • Prototype 2 – Portable enough for athletic use • Maintain accuracy and repeatability • Display movements and muscle firing in a computer model
Problem | Market | Company | Product| Business Plan | Development| Finances Phase I Phase II Phase III Phase IV Months: 0 6 18 30 • Phase II • Apply for FDA approval and patent • License to industry and academia • Clinical Trials 1 (Predictive) • Phase III • Clinical Trials 2 (Preventative) • Market to sports teams • 1st generation release • Phase IV • Review data for 2nd generation release
Problem | Market | Company | Product| Business Plan | Development| Finances Phase I Budget
Problem | Market | Company | Product| Business Plan | Development| Finances Financial Projections Phase I Phase II Phase III Phase IV
Thank you • Dr. Paul Sadja • Associate Professor of Biomedical Engineering • Jim Gossett • Associate Athletics Director for Sports Medicine • Paige Plash • Physical Therapist, COO Encore Rehabilitation • Dr. Elizabeth Hillman • Assistant Professor of Biomedical Engineering • Keith Yeager • Senior Staff Associate, Laboratory Manager