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Antineoplastic drugs=chemotherapy

—they interfere with cancer reproduction. Cancer cells grow quickly and more vulnerable to chemo drugs but also kill Some healthy cells with severe side effects. Antineoplastic drugs=chemotherapy. cancer—100 different types with uncontrolled cell division and no useful function.

donaldromero
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Antineoplastic drugs=chemotherapy

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  1. —they interfere with cancer reproduction. Cancer cells grow quickly and more vulnerable to chemo drugs but also kill Some healthy cells with severe side effects. Antineoplastic drugs=chemotherapy cancer—100 different types with uncontrolled cell division and no useful function. They get massive blood supply. Metastasis= spread. Benign=encapsulated tumor, stay under skin Malignant=spread by lymphoma and blood and ulcerate skin. Will likely be category C D or X for pregnancy Tumor grade=shape compared to parent cell Grade 0=normal 1= like parent tissue 2= moderate 3=extensive change 4=anaplastic/no similarity Stage0= in situ stage1=minor invasion Stage2&3=local spread stage4=widespread metastasis

  2. Antineoplastic agents • Look at type,size,site,grade then determine what drug. • Allopathic tx of cancer=cut, chemo, or nuke it out • Types of cancer drugs— • 1--Antimetabolites--interfere with DNA synthesis=death. Drugs--methotrexate, 5 flourouracil , purinethol • 2--Alkyating agents---attacks metaphase. Very toxic • Drugs—nitrogen mustard(mustard gas), chlorambucil • 3--Plant alkaloids(periwinkle) —attacks metaphase. • Drugs—vinblastine

  3. Antineoplastic agents • 4--Hormone/hormone antagonist—least toxic • Estrogen for prostate, androgen for breast • Antiandrogen tamoxifen • 5--Antitumor antibiotic—bind to DNA, parenteral • 6--Immunosuppresant—interferon with variety of effects • 7--Radioisotopes—pellets or solutions

  4. Cancer drug side effects • Bone marrow • Intestines • Alopecia • Why these side effects???---these cells replicate quickly—like cancer cells. • Fetus • Sterility • Headache • Extremity numbness • Seizures • Naseau • Avoid sick people

  5. considerations • Follow USP 797 • USP 800 • No spray into air • If pregnancy stay away from chemo patients or isotopes patients • Liver and kidney testing frequent • Best chemo dosage with---nomogram • Yellow sharps container is for USP classified hazardous material

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