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Ribosome Structure/Function: The 30S subunit is a machine!

Ribosome Structure/Function: The 30S subunit is a machine!. Biochemistry 655 4 December 2009. Goals. The A-minor motif Review the domain structure of the 30S ribosome A Close collaboration between Proteins and RNA Demonstrate the conformational change

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Ribosome Structure/Function: The 30S subunit is a machine!

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  1. Ribosome Structure/Function:The 30S subunit is a machine! • Biochemistry 655 • 4 December 2009

  2. Goals • The A-minor motif • Review the domain structure of the 30S ribosome • A Close collaboration between Proteins and RNA • Demonstrate the conformational change • Relate the conformational change to codon-anticodon matching • Discuss the roles of mutations in mechanistic studies • Discuss how antibiotics can affect fidelity

  3. The A-Minor Motif

  4. 50S Peptidyl-transferase Ints

  5. We’ve seen the Brawn, Now here’s the Brain-modified from S. Strobel

  6. Head Platform Body Subunit interface

  7. 70S Ribosome

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