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TREATMENT OF BLEEDING

TREATMENT OF BLEEDING . BY:DR ISRAA OMAR . Aminocaproic acid and traneximic acid. Both are synthetic agents Work by inhibition of plasminogen activation They are orally active A potential side effect of treatment is intravascular thrombosis. Aprotinin .

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TREATMENT OF BLEEDING

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  1. TREATMENT OF BLEEDING BY:DR ISRAA OMAR

  2. Aminocaproic acid and traneximic acid • Both are synthetic agents • Work by inhibition of plasminogen activation • They are orally active • A potential side effect of treatment is intravascular thrombosis

  3. Aprotinin • It stops bleeding by blocking plasmin • It can inhibit streptokinase • It is used to reduce blood loss in patients undergoing cardiopulmonary bypass surgery • Side effect include anaphylactic reaction if there is previous exposure within 12 month , renal dysfunction is also reported with the use of this drug

  4. Protamine sulfate • Antagonizes the anticoagulant effect of heparin • It is derived from fish sperm and testes and has a high content of arginine which make it basic drug • It is positive charge neutralize the negative charge of heparin thus making a stable complex and prevent the action of heparin • Side effect include dyspnea , flushing , hypotension and bradycardia especially when injected rapidly

  5. Vitamin k (phytonadione) • It antagonize the action of oral anticoagulant • The action of vitamin k start after 24 hours ;thus ,if immediate action is required ,fresh frozen plasma should be infused

  6. Thank you

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