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The Urinary System Michael Hall University of California Los Angeles. Mannekin Pis. Collecting Duct. Uriniferous tubule. Nephron. THE RENAL CORPUSCLE HAS:. A simple squamous parietal epithelium (PE) which lines Bowmans capsule (BC). A tuft of capillaries called the glomerulus (G)
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The Urinary System Michael Hall University of California Los Angeles Mannekin Pis
Collecting Duct Uriniferous tubule Nephron
THE RENAL CORPUSCLE HAS: A simple squamous parietal epithelium (PE) which lines Bowmans capsule (BC). A tuft of capillaries called the glomerulus (G) A modified epithelium lining the capillaries (VE) A vascular pole (VP) A urinary pole (UP) A urinary space (US) UP VP US VE PE G BC
Renal Corpuscle Efferent arteriole Glomerulus Filtrate Bowman’scapsule Afferent arteriole Urinary space
Filtration apparatus of renal corpuscle Filtration slit membrane Basal lamina Pedicel Podocyte Fenestrated endothelium of capillary
Pedicels Filtration slit membrane Fenestrations Basal lamina RBC capillary
The glomerular basement membrane is a size and charge-selective barrier • SIZE: Only proteins below 60,000 mw • can get through the fenestrae and slits • CHARGE: It is anionic (sialoproteins • and proteoglycans) • Most macromolecules are anionic at neutral pH, so they are repelled
Proximal convoluted tubule Collecting duct Distal convoluted tubule Descending straight segment Ascending straight segment Thin loop of Henle Vasa recta
Tubules in cortex of kidney microvilli DCT PCT Collecting duct
Tubules in medulla of kidney Thin loops of Henle CD DCT PCT
Macula densa PCT DCT Macula densa Distal convoluted tubule
JG cells Distal tubule Macula densa Glomerular capillaries The Juxtaglomerular Apparatus
The role of the JG cells on the permeability of the collecting ducts to water Cells of macula densa sense decreased blood volume/flow ACE from posterior pituitary
Changes in osmolarity in blood and urine during urine formation vasa recta
Manneken Pis has over 500 outfits that are used for special occasions
Renal corpuscles Cortex Arcuate artery and vein Medulla
Lobule Interlobular arteries
Juxtamedullary nephrons and vasa recta Cortical nephron Juxtamedullary nephron Vasa recta Loop of Henle
Collecting ducts Papilla Minor calyx
Ureter transitional epithelium
Transitional epithelium Bladder (relaxed) Bladder (stretched)
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Afferent IL Blood circulation in kidney Efferent juxtamedullary nephrons