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Thromboprophylaxis after delivery

Thromboprophylaxis after delivery. Mojgan Barati 13/12/92. For how long should thromboprohylaxis be continued after delivery?. Thromboprophylaxis should be continued for 6 weeks in women at high risk of postpartum VTE and for 1 week in women with intermediate risk.

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Thromboprophylaxis after delivery

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  1. Thromboprophylaxis after delivery MojganBarati 13/12/92

  2. For how long should thromboprohylaxis be continued after delivery? • Thromboprophylaxis should be continued for 6 weeks in women at high risk of postpartum VTE and for 1 week in women with intermediate risk.

  3. Assessment of risk:High risk • Any previous VTE • Anyone requiring antenatal LMWH • At least 6 weeks postnatal prophylactic LMWH

  4. Intermediate risk • Caesarean section in labour • Asymptomatic thrombophilia (inherited or acquired) • BMI > 40 kg/m2 • Prolonged hospital admission • MEDICAL COMORBIDITIES, e.g. heart or lung disease, SLE, cancer, imflammatory conditions, nephrotic syndrome, sickle cell disease, • intravenous drug user • At least 7 days postnatal prophylatic LMWH

  5. Low risk if only one risk factorMobilisation and avoidance of dehydration • 1- Age > 35 years • 2- Obesity (BMI > 30kg/m2) • 3- Parity ≥ 3 • 4- Smoker • 5- Elective caesarian section • 6- Any surgical procedure in the puerperium • 7- Gross varicose veins • 8- Current systemic infection • 9- Immobility, e.g. paraplegia, SPD, • 10- long distance travel • 11- Pre-eclampsia • 12- Mid-cavity rotational operative delivery • 13- Prolonged labour (> 24 hours) • 14- PPH > 1 litre or blood transfusion

  6. Low risk if 2 or more risk factorsAt least 7 days postnatal prophylatic LMWH • 1- Age > 35 years • 2- Obesity (BMI > 30kg/m2) • 3- Parity ≥ 3 • 4- Smoker • 5- Elective caesarian section • 6- Any surgical procedure in the puerperium • 7- Gross varicose veins • 8- Current systemic infection • 9- Immobility, e.g. paraplegia, SPD, • 10- long distance travel • 11- Pre-eclampsia • 12- Mid-cavity rotational operative delivery • 13- Prolonged labour (> 24 hours) • 14- PPH > 1 litre or blood transfusion

  7. Low risk Note: if persisting or > 3 risk factors, considerextending thromboprophylaxis with LMWH • 1- Age > 35 years • 2- Obesity (BMI > 30kg/m2) • 3- Parity ≥ 3 • 4- Smoker • 5- Elective caesarian section • 6- Any surgical procedure in the puerperium • 7- Gross varicose veins • 8- Current systemic infection • 9- Immobility, e.g. paraplegia, SPD, • 10- long distance travel • 11- Pre-eclampsia • 12- Mid-cavity rotational operative delivery • 13- Prolonged labour (> 24 hours) • 14- PPH > 1 litre or blood transfusion

  8. Key • BMI = body mass index (based on booking weight), • gross varicose veins = symptomatic, above the knee or associated with phlebitis/oedema/skin changes, • immobility = ≥ 3 days, • long-distance travel = > 4 hours, • SPD = symphysis pubis dysfunction with reduced mobility

  9. Just as circumstances and risk factors can change antenatally, such changes can also occur in the puerperium. For this reason, women undergoing surgery for any reason during the puerperium, those who develop severe infection, those who are readmitted or who choose to travel long distance are at increased risk of VTE, even though they may have been discharged from hospital following normal vaginal delivery several weeks before.

  10. Persistant risks lasting more than 7 days postpartum • In women who have additional persistent (lasting more than 7 days postpartum) risk factors, such as prolonged admission or wound infection, thromboprophylaxis should be extended for up to 6 weeks or until the additional risk factors are no longer present.

  11. Which women with previous VTE need postpartum thromboprophylaxis? C • All women with a previous history of confirmed VTE should be offered thromboprophylaxis with LMWH or warfarin for 6 weeks postpartum, regardless of the mode of delivery.

  12. Which women with thrombophilia without previous VTE need postpartum thromboprophylaxis? C • All women with known heritable or acquired thrombophilia should be considered for LMWH for at least 7 days following delivery, even if they were not receiving antenatal thromboprophylaxis. This could be extended to 6 weeks if there is a family history or other risk factors present.

  13. What is the magnitude of risk of VTE after caesarean section? C • All women who have had an emergency caesarean section should be considered for thromboprophylaxis with LMWH for 7 days after delivery. • All women who have had an elective caesarean section who have one or more additional risk factors (such as age over 35 years, BMI greater than 30) should be considered for thromboprophylaxis with LMWH for 7 days after delivery.

  14. Cesarean risk of VTE • Women delivered by elective caesarean section have at least double the postpartum risk of VTE compared with vaginal birth. • Women delivered by emergency caesarean section have double the risk of postpartum VTE compared with elective caesarean section. • Women delivered by emergency caesarean section have a roughly four-fold increased risk of postpartum VTE compared with women delivered vaginally.

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