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HEMOSTAZ. Yard. Doç. Dr. Murat ÖRMEN. SUNUM PLANI. Hemostaza genel bakış Hemostatik sistemlerin bileşenleri Primer hemostaz Sekonder hemostaz. Hemotaz, kanama,tromboz animasyon. Coagulation Factors. Fibrinogen Group Factors I, V, VIII and XIII Prothrombin Group
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HEMOSTAZ Yard. Doç. Dr. Murat ÖRMEN
SUNUM PLANI • Hemostaza genel bakış • Hemostatik sistemlerin bileşenleri • Primer hemostaz • Sekonder hemostaz
Coagulation Factors • Fibrinogen Group • Factors I, V, VIII and XIII • Prothrombin Group • Factors II, VII, IX and X • Contact Group • Factors XI, XII • Prekallikrein (Fletcher Factor) • High Molecular Weight Kininogen • (Fitzgerald Factor)
• t-PA • Streptokinase • Urokinase • Anaphylaxis • GI Bleeding • Intracranial Hemorrhage Thrombolytic Therapy
Dense Body ADP Serotonin ATP Calcium Dense Tubular System Microtubular System Plasma Membrane PF3 Glycogen Exterior Coat (Glycocalyx) Alpha Granules PF4 Fibrinogen Factor V Fibronectin Factor VIII R:ag b Thromboglobulin (vWF) Mitochondria Surface Connecting System Cytosol Factor XIII Anatomy of a Platelet
Platelet Function A Adhesion ADP Release Shape Change Release 3 seconds Aggregation B 10 seconds C Coagulation Fibrin Formation 5 minutes