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Biologic Monitoring

Biologic Monitoring. A. H. Mehrparvar, MD Occupational Medicine department Yazd University of Medical Sciences. Introduction. Environmental monitoring vs biologic monitoring Prediction of biologic levels by environmental monitoring Sources of variability: Different sources of exposure RR

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Biologic Monitoring

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  1. Biologic Monitoring A. H. Mehrparvar, MD Occupational Medicine department Yazd University of Medical Sciences

  2. Introduction • Environmental monitoring vs biologic monitoring • Prediction of biologic levels by environmental monitoring • Sources of variability: • Different sources of exposure • RR • Rate of metabolism and excretion • Adipose tissue level • PPD

  3. Introduction • Assesses the extent of exposure • Indirectly assesses health effects • Probability of illness, never diagnostic • Abnormal biologic monitoring levels: Multiple measurements • Timing of collection very important: DS, EOS, EWW, PNS

  4. Biologic monitoring program • Necessary conditions: • Determinant • Method of analysis • Sample collection • Interpretation of results • Responding action • Sufficient conditions: • Environmental monitoring • Conducted • Not adequate • Not feasible • Substances • Exposure routes

  5. Biomarkers • Biologic marker or biomarker: any substance, structure or process that can be measured in the human body or human body products, and may influence or predict disease Biologic monitoring: Measuring a chemical, its metabolite or its non-adverse effect in a tissue sample in order to monitor exposure

  6. Biomarkers (cont.) • Classification: • Biomarker of exposure • Biomarker of effect • Biomarker of suceptibility

  7. Biomarker of exposure • Biomarker of internal dose • Blood lead • Urine Mn • Biomarker of effective dose • CoHgb

  8. Biomarker of exposure (cont.) • Characteristics: • Correlation with exposure • Correlation with target tissue dose • Reversibility • Appropriate sampling method

  9. Biomarker of effect • Measurement of reversible biochemical changes after an internal dose • Not pathological effects • Example: inhibition of δ-ALA by lead

  10. Biomarker of susceptibility • Possible differences between individuals in responding to an exposure

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