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Case Study 2 Management of Drug-Drug Interactions in HIV and Hepatitis

Case Study 2 Management of Drug-Drug Interactions in HIV and Hepatitis. www.hiv-druginteractions.org www.hep-druginteractions.org. 1. Summary of Case. The Problem - HIV 33 million people worldwide with HIV Antiretroviral therapy (3 or more drugs) effective

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Case Study 2 Management of Drug-Drug Interactions in HIV and Hepatitis

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  1. Case Study 2Management of Drug-Drug Interactions in HIV and Hepatitis • www.hiv-druginteractions.org • www.hep-druginteractions.org

  2. 1. Summary of Case • The Problem - HIV • 33 million people worldwide with HIV • Antiretroviral therapy (3 or more drugs) effective • HIV drugs are among the most risky drugs for clinically significant drug-drug interactions (DDIs) - affecting up to 40% of patients on treatment. • Problem will get worse as HIV population ages and care is devolved to general practice. • Mission Statement - To Aid the Prescriber • ‘Provision of a clinically useful, reliable, comprehensive, up-to-date, evidence-based drug-drug interaction resource, freely available to healthcare workers, patients and researchers’

  3. 2. Underpinning Research • Expertise in HIV Pharmacology including: • Bioanalysis (CPA Accreditation 2004; spin-out company 2005; GCLP accreditation for BAF 2010). • National and International clinical trials including multiple drug-drug interactions. • Pharmacokinetic-Pharmacodynamic modelling • Pharmacogenetics

  4. How the Drug Interactions web site started

  5. Currently >6000 interaction pairs in the database.

  6. 3. References to the Research

  7. Citations in articles

  8. Treatment Guidelines

  9. Treatment Guidelines

  10. 4. The Contribution, Impact, Benefit • Cited in multiple national/international treatment guidelines • Cited in WHO treatment guidelines • Cited by HPA during the 2009 flu pandemic

  11. Widely used: increasing year on year

  12. Smartphone Application “HIV iCharts“ Launched Feb 2011 (Downloads ~2800 as of April 2011) Launched Nov 2010 (Downloads ~4000 as of April 2011)

  13. Personal Testimony. • HIV iChart entered for Excellence in Digital Communications Award.

  14. App for Android phones and tablets App for iPhone, iPad, and iPod Touch £267k (2009-2010) SMS service for G2 phones Standalone app for PCs Integrated health systems Knowledge exchange CDA in place to discuss licensing agreement NIHR Award – April 2011

  15. Translation Russian Requested by Elton John AIDS Foundation. Spanish

  16. The Problem - Hepatitis • Chronic Hepatitis C affects ~ 170 million people • Currently only 2 drugs – PEG interferon & Ribavirin

  17. Launched JAN 2011

  18. Mission Statement - To Aid the Prescriber ‘Provision of clinically useful, reliable, comprehensive, up-to-date, evidence-based drug-drug interaction resources, freely available to healthcare workers, patients and researchers’

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