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CLINDAMYCIN

CLINDAMYCIN ( CONT. ). Clinical usesLimited because of pseudomembranous colitis- fatalAnaerobic infections caused by Bacteroids( metronidazole is preffered. Staphylcoccal joint

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CLINDAMYCIN

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    1. CLINDAMYCIN Antibacterial activity Active against G+ cocci, including penicillin- resistant Staph. and many anaerobes, esp.Bacteroides sp. Not effective against G- aerobes. Mechanism of action Inhibits protein synthesis ( 50 s subunit ) Pharmacokinetics May be given orally or parenterally Widely concentrated in tissues ( including bones ) & body fluids It diffuses across the placenta but not BBB 90% protein bound Metabolized in liver ( active )( enterohepatic circulation), 10 % excreted unchanged Excretion – urine and bile Half- life 2.5 hr, prolonged in severe hepatic insufficiency

    2. CLINDAMYCIN ( CONT. ) Clinical uses Limited because of pseudomembranous colitis- fatal Anaerobic infections caused by Bacteroids( metronidazole is preffered. Staphylcoccal joint & bone infections such as osteomyelitis Staph. Conjunctivitis ( eye drops ) Diabetic foot infections Acne ( 1% topical gel & lotion ) Side effects Mainly GI disturbances- Diarrhoea is common Antibiotic- associated colitis-fatal (limits its use) Hepatotoxicity & bone marrow suppression- rare

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