Performers, publishers, polyphony and the Pope What can medicine learn from the music business?

1. Performers, publishers, polyphony and the Pope What can medicine learn from the music business?

2. To Err is Human (IOM, 1999) • Up to 97,000 unnecessary deaths p.a. in the US are due to medical error • “even using the lower figure [48,000] deaths due to medical errors exceed the numbers attributable to the 8th leading cause of death … more than from motor vehicle accidents (43,548), breast cancer (42,297) or AIDS (16,516) • Total national costs … between $17B and $29B

3. … and the UK 10% of acute admissions to NHS Hospitals result in adverse events which cause patient harm. C Vincent et al, BMJ, 322: 517-519, 2001 Perhaps 16,000 lives could be saved if all current knowledge of cancer were properly applied ICRF Vision for Cancer, 1995

4. Disseminating medical knowhow… • Cochrane Library of systematic reviews • Scottish Intercollegiate Guidelines Network • UK National Institute for Clinical Excellence • US National Guideline Clearinghouse • BMJ publishing’s Clinical Evidence

5. … but ·  Busy clinicians have little time to read … converting paper to electronic pages may not change this reality. ·  Even if a clinician has time to read the content may not be correctly absorbed and applied in practice. ·  Conventional published guidelines do not provide recommendations that are tailored to the needs of individual patients.

6. A new option? • IT Support for “best practice” • Electronic patient records • Rapid access to guidelines • Prompts and reminders • Decision support • Scheduling and workflow • Support for communication and coordination

7. Crossing the quality chasm "reorganization and reform are urgently needed to fix what is now a disjointed and inefficient (healthcare) system … use of information technology is key … if a substantial improvement in quality is to be achieved over the coming decade.” US Institute of Medicine, March 2001

8. Music, a historical precedent

9. Guido d'Arezzo was a Benedictine monk, musical theorist and teacher. His name is associated with the most comprehensive rationalisation of the myriad, ad hoc and often imprecise means of musical notation that had developed amongst the monasteries of Europe from around the 7th century onwards.

10. Representing medical guidelines • Arden syntax Hripcsak et al • ASBRU Shahar et al • EON/Protégé Musen et al • GLIF Intermed consortium • GUIDE Pavia • Prodigy Sowerby Centre • PROforma ICRF

11. PROforma process modelling language Enquiries Actions Decisions Plans

12. A PROforma guideline: management of suspected breast cancer by GPs

13. Some PROforma performances Das Alte Werk

15. Genetic risk assessment and counselling

18. Breast Cancer screening

19. Composing and publishing

20. PROforma

21. Publet technology Publet library

25. Transpositions, arrangementsand instruments

26. John Kingston’s PROforma browser

27. InferMed’s MACRO Clinical trials manager

28. REACT interactive care planner

29. Polyphony

30. SIGN, BrCa • GP referrals • Screening • Triple assessment • Surgey • Radiotherapy • Systemic therapy • Follow-up • Information & • support

32. Managing the orchestra • Players • Shared score, common notation • Voices • Parts as separate but coordinated plans • Communication and coordination • Conductor, leader or none? • Performance • Interpretation not execution

33. The audience

34. REACT:empowering the patient?

35. Performers, publishers, polyphony andthe Pope

36. Pope John XIX “summoned Guido of Arezzo to Rome [In 1028] … and urged him to instruct the Roman clergy in music.”

37. With thanks to … Jon Bury, Andrew Coulson, David Glasspool, Michael Humber, Ali Rahmanzadeh, Margarita Sordo, David Sutton, Richard Thomson Imperial Cancer Research Fund Paul Taylor UCL CHIME Robert Walton Oxford U Jon Emery Cambridge U Robert Dunlop, Nicky Johns, Michael Morris, Andrew Newbigging InferMed Ltd John Kingston Edinburgh U Subrata Das CRA Inc.