1 / 6

Anatomy of the Immune system Lecture #7 IMMUNOLOGY (BIOL 40400-01)

Anatomy of the Immune system Lecture #7 IMMUNOLOGY (BIOL 40400-01) Instructional Objectives for Anatomy of the Immune System ; Students should be able to: Define Immunology Discuss what stem cells are and their significance to immunology

dusty
Download Presentation

Anatomy of the Immune system Lecture #7 IMMUNOLOGY (BIOL 40400-01)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Anatomy of the Immune system Lecture #7 • IMMUNOLOGY (BIOL 40400-01) • Instructional Objectives for Anatomy of the Immune System; Students should be able to: • Define Immunology • Discuss what stem cells are and their significance to immunology • Identify and discuss the significance of the “key” cells/organs/proteins of the immune system • Assigned reading: pages: 228-235; 245-253. The T-cell Maturation

  2. T-cell Need accessory molecules And co-receptors e.g. CD#; CD4; CD8 APC

  3. As maturing T-cells journey through the thymus there newly expressed T-cell receptors (TCR) interact with APCs. This activity results in a selection process. • The thymus will perform 2 selection processes: • 1. Positive selection: T-cells who’s new TCR binds to the MHC molecules on APCs with or without self antigens will be… • selected for keeping. This is called MHC restriction. • 2. Negative selection: T-cells that bind extremely tight (high-affinity) to APCs will be… • eliminated via apoptosis. This results in self tolerance. • At the end of positive and negative selection, T-cells that survive (~5% of the starting population) will be: • Self MHC restricted • Self tolerant

More Related