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Neutropenia-HIV

Objectives. Define NeutropeniaDiscuss risk of neutropenia in HIVReview differential dx of etiology of neutropeniaUnderstand treatment of neutropenic fever. Defintion. Neutropenia is defined as a neutrophil count of: 500 cells/mm3, or a count of 1000 cells/mm3 with a predicted dec

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Neutropenia-HIV

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    1. Neutropenia-HIV Joe Caperna, MD University of California, San Diego 4 Nov 2010

    2. Objectives Define Neutropenia Discuss risk of neutropenia in HIV Review differential dx of etiology of neutropenia Understand treatment of neutropenic fever

    3. Defintion Neutropenia is defined as a neutrophil count of: 500 cells/mm3, or a count of 1000 cells/mm3 with a predicted decrease to 500 cells/mm3. Hughes W et al. “I D S A G U I D E L I N E S, 2002 Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer.” Clinical Infectious Diseases 2002; 34:730–51.

    4. Non-HIV Neutropenia At least one-half of neutropenic patients who become febrile have an established or occult infection, and At least one-fifth of patients with neutrophil counts of 100 cells/mm3 have bacteremia. The organisms that cause bacteremia are many, see Table 2. Fungi are common causes of secondary infection among neutropenic patients who have received courses of broad-spectrum antibiotics and may also cause primary infections. The primary anatomic sites of infection often include the alimentary tract, where cancer chemotherapy–induced mucosal damage allows invasion of opportunistic organisms

    6. Neutropenia - HIV Neutropenia has been reported in approximately 10% to 50%. Levine 2006

    7. The following slides borrowed from: DR A. W. KHAN WAZIR

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