Systemic IO&NS pathways in Inflammation CMI activation

1. TRIGGER FACTORS Autoimmunity Infections Psychosocial stressors ↑Central hypoperfusion ↓Cerebral glucose metabolism ↑Brain atrophy ↑Cerebral lactate and choline ↓Cerebral N-acetyl aspartate ↑O&NS ↓Antioxidants ↑PICs ↑CMI activation Th1 andTh2 shift ↓Treg ↑T cell exhaustion ↑CD26 ↓NKCA ↑B cells ↑Autoimmune responses ↑Autoimmunity to neoepitopes ↓Mitochondrial ATP ↑Mitochondrial damage ↓Phosphocreatine synthesis ↓Oxidative phosphorylation ↓Maximal voluntary contraction MS Central Demyelination Damage respiratory chain Other specific factors Systemic IO&NS pathways in Inflammation CMI activation O&NS Decreased antioxidants TRYCATs Autoimmune responses Systemic IO&NS pathways in Schizophrenia MS and ME/CFS Common systemic and central pathophysiology Accelareted glycolysis Specific autoimmune reactions Lowered CD69 Other specific factors ME/CFS