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Genetics

Explore the ABO and Rh blood group systems, inheritance patterns, antigens, antibodies, genotypes, and compatibility for blood transfusions. Learn about the 8 blood groups and who can donate to whom.

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Genetics

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  1. Genetics

  2. The Blood Group Systems   Inheritance and Genetics

  3. ABO blood grouping system According to the ABO blood typing system there are four different kinds of blood types:   A, B, AB or O (null)

  4. ABO inheritance and genetics • The ABO gene is autosomal • The ABO gene locusis located on the chromosome 9 • A and B blood groups are dominant over the O blood group • A and B group genesareco-dominant • Each person has two copies of genes coding for their ABO blood group (one maternal and one paternal in origin)

  5. Agglutinogens (Antigens)

  6. The ABO blood groups The table shows the four ABO phenotypes ("blood groups") present in the human population and the genotypes that give rise to them. Blood Group Antigens on RBCs Antibodies in Serum Genotypes hetro homo A A Anti-B IAIA or IAi B B Anti-A IBIB or IBi AB A and B Neither IAIB O Neither Anti-A and anti-B ii

  7. The Rhesus (Rh) System There's another antigen to be considered : the Rh antigen.Some of us have it, some of us don't. If it is present, the blood is RhD positive, if not it's RhD negative. So, for example, some people in group A will have it, and will therefore be classed as A+ (or A positive). While the ones that don't, are A- (or A negative). And so it goes for groups B, AB and O.

  8. BloodType A person with Rh- blood does not have Rh antibodies naturally in the blood plasma Genotype AllelesProduced Rh Blood Group and Rh Incompatibility Rh positive RR R Rr R or r Rh negative rr r

  9. A person with Rh- blood can develop Rh antibodies in the blood plasma if he or she receives blood from a person with Rh+ blood, whose Rh antigens can trigger the production of Rh antibodies. • A person with Rh+ blood can receive blood from a person with Rh- blood without any problems.

  10. The ABO Blood Group System Laboratory  Determination of the ABO System

  11. Step ( 1 )

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  22. Blood group: O + ve

  23. Anti-A Anti-B Anti-D Blood type A+ A_ B+ B_ AB+ AB_ O+ O_

  24. Do you know which blood group you belong to? According to above blood grouping systems, you can belong to either of following 8 blood groups:

  25. Blood transfusions – who can receive blood fromwhom? People with blood group O are called "universal donors" and people with blood group AB are called "universal receivers."

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