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Imaging, Management & Clinical Reserch 1 st International Symposium on Prevention of Cardiovascular Diseases June Krakow Poland. Role of Nuclear Tests in Secondary Prevention. Dr med. Magdalena Kostkiewicz Dept. of Nuclear Medicine The John Paul II Hospital Krakow Poland. Ischemic cascade.
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Imaging, Management & Clinical Reserch 1st International Symposium on Prevention of Cardiovascular Diseases June Krakow Poland Role of Nuclear Tests in Secondary Prevention Dr med. Magdalena Kostkiewicz Dept. of Nuclear Medicine The John Paul II Hospital Krakow Poland
Ischemic cascade angina ST depresion Systolic dysfunction ischemia Diastolic dysfunction Metabolic alteration hipoperfusion time
Types of imaging modalities molecular function functional integrity structure RTG CT MRI SPECT, PET
Radionuclide angiography • Left and right volume • Left and right ejection fraction • Regional left ventricular contractility • Left ventricular diastolic function
Contrast echocardiography and MIBI SPECT 3 days after PCI in acute MI Normal perfusion – defect of perfusion
Perfusion and LV function Gated SPECT
Perfusion and LV function (Gated SPECT) Ischemic cardiomiopathyEF- 47% Normal heart
HLA SA HLA SA VLA VLA 18FDG 99mTc-MIBI necrosis hibernating miocardium Metabolic function - FDG PET
Asessment of autonomic function of the heart Normal heart Heart failure
Assessment of autonomic system of the heart Heart failure 6 months after treatment with ACE inhibitors Somsen G. et al. Int. J. Cardiac Imaging
Imaging modalities used for assessment of human atherosclerotic plaque (invasive)
Imaging modalities used for assessment of human atherosclerotic plaque (non invasive)
Stem cells visualisation- PET Wu et al. J N Cardiol 2004
Detection of apoptosis Perfusion defect Localisation of apoptosis Hofsra et al. Lancet 2003
PET/CT (fusion) Schwaiger M. i wsp.
Patient with symptomatic carotic stenosis (a) and contralateral asymptomatic carotic stenosis (b) a b Davies et al. J Nucl Cardiol.12,2;2005
Patient with stenosis of left vertebral artery MRI FDG-PET FUSION Davies et al. J Nucl Cardiol.12,2;2005