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Role of Nuclear Tests in Secondary Prevention

Imaging, Management & Clinical Reserch 1 st International Symposium on Prevention of Cardiovascular Diseases June Krakow Poland. Role of Nuclear Tests in Secondary Prevention. Dr med. Magdalena Kostkiewicz Dept. of Nuclear Medicine The John Paul II Hospital Krakow Poland. Ischemic cascade.

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Role of Nuclear Tests in Secondary Prevention

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  1. Imaging, Management & Clinical Reserch 1st International Symposium on Prevention of Cardiovascular Diseases June Krakow Poland Role of Nuclear Tests in Secondary Prevention Dr med. Magdalena Kostkiewicz Dept. of Nuclear Medicine The John Paul II Hospital Krakow Poland

  2. Ischemic cascade angina ST depresion Systolic dysfunction ischemia Diastolic dysfunction Metabolic alteration hipoperfusion time

  3. Types of imaging modalities molecular function functional integrity structure RTG CT MRI SPECT, PET

  4. Radionuclide angiography • Left and right volume • Left and right ejection fraction • Regional left ventricular contractility • Left ventricular diastolic function

  5. Radionuclide angiography

  6. Radionuclide angiography

  7. Contrast echocardiography and MIBI SPECT 3 days after PCI in acute MI Normal perfusion – defect of perfusion

  8. Perfusion and LV function Gated SPECT

  9. Perfusion and LV function (Gated SPECT) Ischemic cardiomiopathyEF- 47% Normal heart

  10. HLA SA HLA SA VLA VLA 18FDG 99mTc-MIBI necrosis hibernating miocardium Metabolic function - FDG PET

  11. Asessment of autonomic function of the heart Normal heart Heart failure

  12. Assessment of autonomic system of the heart Heart failure 6 months after treatment with ACE inhibitors Somsen G. et al. Int. J. Cardiac Imaging

  13. Imaging modalities used for assessment of human atherosclerotic plaque (invasive)

  14. Imaging modalities used for assessment of human atherosclerotic plaque (non invasive)

  15. Radionuclide tracer compunds used to image atherosclerosis

  16. Stem cells visualisation- PET Wu et al. J N Cardiol 2004

  17. Detection of apoptosis Perfusion defect Localisation of apoptosis Hofsra et al. Lancet 2003

  18. PET/CT (fusion) Schwaiger M. i wsp.

  19. Patient with symptomatic carotic stenosis (a) and contralateral asymptomatic carotic stenosis (b) a b Davies et al. J Nucl Cardiol.12,2;2005

  20. Patient with stenosis of left vertebral artery MRI FDG-PET FUSION Davies et al. J Nucl Cardiol.12,2;2005

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