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From Mice to Man: Imaging Infection with [ 124 I]FIAU PET-CT. Catherine A. Foss, Ph.D. Permissive Pathogens Selectively Trap FIAU. HSV1 tk EBV tk KSHV tk bacteria. cell. (free). (trapped). Proof of principle: we are imaging bacterial thymidine kinase (TK). tumor + C. novyi-NT
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From Mice to Man: ImagingInfection with [124I]FIAU PET-CT Catherine A. Foss, Ph.D. Permissive Pathogens Selectively Trap FIAU HSV1 tk EBV tk KSHV tk bacteria cell (free) (trapped)
Proof of principle: we are imaging bacterial thymidine kinase (TK) tumor + C. novyi-NT + radio-FIAU tumor + C. novyi-NT radio-FIAU uptake is mechanism-based (substrate for bacterial thymidine kinase) (Bettegowda et al., Proc Natl Acad Sci USA, 2005; 102:1145)
ClinicalPET-CT images showing bacterial infection in natural and prosthetic joints. B D A R L R L C E R L R L R L Red arrows indicate the site of infection. A. patient 3 at 2h p.i., infected left hip; B. and C. Patient 4 at 2 and 24h p.i., respectively, infected right knee; D. patient 7 At 2h p.i., infected left ankle; E. patient 8 at 2h p.i., infected right knee.
