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Revolutionary Pharmaceutical R&D Process in Costly Drug Development

Explore the innovative pharmaceutical R&D process, risks and reasons for failure in drug development, and therapeutic innovation. Learn about compound libraries, drug candidate development, and ways to innovate in the industry. Discover how existing compounds, like Nitroimidazoles, are being creatively utilized for new drug candidates.

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Revolutionary Pharmaceutical R&D Process in Costly Drug Development

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  1. 10-12 years, costly ($30 Mn – $1300Mn) The pharmaceutical R&D process Development Discovery Use

  2. Discovery research = innovative part development Compound libraries Drug candidate

  3. Risks in research and development of pharmaceutical drugs • Reasons for failure include: • Lack of bioavailability • Toxicity • Lack of efficacy • But also: • Patent position • Market prospect / competitors • Mergers/acquisitions development

  4. Therapeutic innovation :many different ways to innovate including new or better uses of existing molecules / treatments • Existing compounds: Library screening & compound mining • New compounds through medicinal chemistry • New uses of existing compounds • New indications of existing drugs • Improved formulationsof existing drugs • Completing registration dossier • Geographical extension • Combination treatments • Simplifying use • Changing guidelines • EML

  5. Compound mining:creative utilization of existing knowledge Nitroimidazoles: rediscovered drug candidates for protozoal diseases Extensive literature / patent review, including personal consultations with researchers (previously) active on this class of compounds to uncover possible compounds of interest >600 compounds identified from >15 sources; assessed in in vitro / in vivo disease models; several series with promising activity identified 1 new drug candidate in clinical development for sleeping sickness: fexinidazole (off-patent):

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