美国伊利诺大学香槟分校 Jianjun Cheng 报告

1. 美国伊利诺大学香槟分校Jianjun Cheng报告 TITLE：Ring-Opening Polymerization Mediated Syntheses and Applications of Biomaterials 主讲人：Professor Jianjun Cheng 邀请人：申有青(教授) University of Illinois at Urbana-Champaign (UIUC) in 2005, assistant professor Full member of the Cancer Center of the University of Illinois at Chicago Achieved one of the Top Five Nanotechnology Breakthroughs in 2006 by Forbes Magazine Prostate Cancer Foundation Competitive Award (2007) National Science Foundation CAREER Award (2008) Teaching Excellence Awards at UIUC for five times (2008, 2009 and 2010) Xerox Award for Outstanding Research (2010) NIH Director’s New Innovator Award (2010) Abstract：Living ring-opening polymerization (ROP) is utilized for controlled synthesis of polymeric materials and for incorporating therapeutics agents to polymers for various biomedical applications. Two ROP related topics will be covered in this presentation.First, ROP of amino acid N-carboxyanhydrides (NCAs) for the controlled synthesis of linear and branched polypeptides will be discussed.Controlled ROP of NCAs can be readily achieved via the use of N-trimethylsilyl amines. This new method allows for the synthesis of polypeptides with unprecedented simplicity with precisely controlled molecular weights and narrow molecular weight distributions. By controlling polypeptide side-chains, we developed ionic helical polypeptides that are capable of delivering DNA and siRNA effectively into cells.In a separate study, we developed polymer-drug conjugated nanoparticles via drug-initiated, controlled ring-opening polymerizations followed by nanoprecipitation. This process allows for successful formulations of sub-100 nm polymeric nanoconjugates with well-defined drug loading, quantitative drug loading efficiency and controlled release profiles. These new type of nanoparticles are promising delivery vehicles for targeted disease treatment with improved efficacy and reduced toxicity. 报告时间：12月16日（星期四）上午10：00 报告地点： 玉泉校区永谦B区2楼报告厅