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Influenza A/H1N1 W. Rose 20091026 H1N1 is a subtype of influenza type A

Influenza A/H1N1 W. Rose 20091026 H1N1 is a subtype of influenza type A Influenza types B and C also exist but less common, less infectious, and drift less rapidly than type A

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Influenza A/H1N1 W. Rose 20091026 H1N1 is a subtype of influenza type A

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  1. Influenza A/H1N1 W. Rose 20091026 H1N1 is a subtype of influenza type A Influenza types B and C also exist but less common, less infectious, and drift less rapidly than type A Drift: gradual change in properties due to relatively rapid mutation rate (due to lack of proofreading of RNA polymerase product) Reassortment: combinations of genes from different viruses in a multiply-infected cell

  2. http://medicineworld.org/images/blogs/9-2006/influenza-virus-82101.jpghttp://medicineworld.org/images/blogs/9-2006/influenza-virus-82101.jpg • Parts of virus • Membrane with glycoproteinshemagglutinin (H), neuraminidase (N); ion channels (M2) • Capsid (protein shell) • Ribonucleoproteins (ssRNA, RNA polymerase, etc)

  3. Influenza A/H1N1 life cycle • http://www.xvivo.net/zirus-antivirotics-condensed/ • How it enters the cell • What it does there • How it reproduces

  4. Influenza Vaccines • Seasonal Flu Vaccine • Mix of two A types, one B type • Injectable: killed (inactivated) virus • Nasal spray: live attenuated • H1N1 2009 Flu Vaccine • Injectable: killed (inactivated) virus • Nasal spray: live attenuated • Antiviral treatment • Oseltamivir (Tamiflu), zanamivir (Relenza) : neuraminidase inhibitors, blocks viral budding from cell • Amantadine etc.: blocks M2 ion channel, thus preventing uncoating; resistance common

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