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Fluconazole

Fluconazole. Azurin , Edelyn Babaran , Krystel. Mode of Action. inhibit the fungal cytochrome P-450 3-A dependent enzyme 14-alpha demethylase. interrupt the synthesis of ergosterol. depletion of ergosterol in the cell membrane accumulation of toxic intermediate sterols.

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Fluconazole

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  1. Fluconazole Azurin, Edelyn Babaran, Krystel

  2. Mode of Action inhibit the fungal cytochrome P-450 3-A dependent enzyme 14-alpha demethylase interrupt the synthesis of ergosterol depletion of ergosterol in the cell membrane accumulation of toxic intermediate sterols increased membrane permeability inhibition of fungal growth http://www.doctorfungus.org/thedrugs/antif_pharm.htm

  3. Antimicrobial Coverage

  4. Side Effects • more common side effects, mild and short-lived. Drug is generally well tolerated. • Diarrhea • Nausea & vomiting • stomach pain • abnormal taste in the mouth • Headache • Acne http://www.mydr.com.au/cmis/ReducedPDFs/CMR09213.pdf

  5. Side Effects • serious side effects, rare, may need urgent medical attention: • Skin reactions/ rash • Bleeding or bruising more easily than normal • Flaking of the skin • Yellowing of the skin or eye, which may indicate hepatitis • Worsening of your infection, with symptoms such as fever, severe chills http://www.mydr.com.au/cmis/ReducedPDFs/CMR09213.pdf

  6. Side Effects • very serious side effects; very rare; need urgent medical attention or hospitalization. • Symptoms of a hypersensitivity reaction • swelling of the face, lips, mouth or throat  difficulty in swallowing or breathing • Allergic reactions which can cause shortness of breath or difficulties breathing • Fits or seizures • Fast or irregular heartbeat http://www.mydr.com.au/cmis/ReducedPDFs/CMR09213.pdf

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