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Reengineering Adeno-Associated Virus (AAV)

Junghae Suh, Ph.D .; Assistant Professor; Dept. of Bioengineering; Rice. (Xie, Qing et al., PNAS 2002). ~25 nm. Reengineering Adeno-Associated Virus (AAV). Genetically encoded nanoparticle. Barriers to delivery. High efficiency in human cells No known pathology Highly monodisperse

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Reengineering Adeno-Associated Virus (AAV)

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  1. Junghae Suh, Ph.D.; Assistant Professor; Dept. of Bioengineering; Rice (Xie, Qing et al., PNAS 2002) ~25 nm Reengineering Adeno-Associated Virus (AAV) Genetically encoded nanoparticle Barriers to delivery • High efficiency in human cells • No known pathology • Highly monodisperse • Control properties through genetic engineering • Particle tracking • Obtain x, y positional data over t • Mean-Square Displacement (MSD), Diffusivity, Velocity, Modes of Transport

  2. Junghae Suh, Ph.D.; Assistant Professor; Dept. of Bioengineering; Rice Gd Targeting motif Contrast metal Gd Gd MRI contrast agent Fluorescence imaging agent Targeting motif Fluorophore Virus-based Imaging Agents • Biomedical Imaging • Problem: Need enhanced contrast with improved targeting for early detection • Our solution: Virus-based contrast agents with high selectivity to target cells • Extracellular barriers to delivery Exploit unique properties of viruses for nanomedicine

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