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2. Research Mission Mechanisms of Development Research into the processes by which a single fertilized egg gives rise to a multicellular organism Mechanisms of Regeneration Research into the processes by which organisms replace cells and tissues lost as a result of aging, disease or injury Scientific Bases of Regenerative Medicine Research into fundamental biological processes with the potential for application in human medical therapies

3. Mechanisms of Development Many questions How do cells containing the same genes take on different roles? How do cells work together to form complex tissues and organs? How do animals transmit genetic traits to their offspring? How does gene expression function in the process of evolution? Wide array of fields and approaches Molecular biology, genomic analysis, biochemistry, embryology, comparative anatomy, evolutionary theory

4. Mechanisms of Regeneration Species on nearly every branch of the evolutionary tree have the ability to regenerate complex tissues and organs as adults. Can we learn to do the same?

5. Scientific Bases of Regenerative Medicine What can nature teach us about healing ourselves? ES cells, embryonic germ cells, adult progenitor cells Controlled differentiation and proliferation Cell replacement therapy Tissue engineering Potential treatments for cardiovascular disease, Parkinson’s disease, diabetes, spinal injury and other currently ‘incurable’ afflictions

6. Potential Stem Cell-based Therapies HPCs Heart Blood vessels Dopaminergic neurons Sensory & motor neurons Retinal cells Innerear Beta cells (insulin) • Diabetes • Angina • Arterial occlusion • Parkinson’s disease • ALS • Spinal paralysis • Retinal diseases • Hearing loss • CVD • MI • Leukemia • Anemia

7. Translational Research Clinical application in human medical therapy Clinical testing confirms safety and effectiveness of potential therapies Biomedical research explores and builds on foundations that show promise Basic research lays scientific foundations and expands the horizons of knowledge

8. CDB Facilities Construction completed December 6, 2002 World-class mouse and aquatic animal facilities Ample common-use equipment and support services

9. Experimental Animal Facilities Automated animal facilities enable humane, hygienic, efficient and economical handling of large numbers of experimental animals 24,000 cage SPF facility provides capacity to handle and care for up to 100,000 mice CDB aquarium houses aquatic model organisms including zebrafish and African clawed frog

10. Model Organisms ROUNDWORM Caenorhabditis elegans FLATWORM Dugesia japonica FLY Drosophila melanogaster ZEBRAFISH Danio rerio CHICKEN Gallus gallus MOUSE Mus musculus

11. Core Equipment & Support Site-wide technical support for electron microscopy Custom transgenic and knockout mouse production High-throughput genomic sequencing and analysis Fluorescence-activated cell sorting Facilities for radioisotope, viral, low-temperature and micromanipulation experiments

12. CDB Academic Affiliations • Kyoto University Graduate School of Biostudies • Kyoto University Graduate School of Medicine • Kobe University, Graduate School of Science and Technology • Department of Life Science • Department of Developmental and Regenerative Medicine • Nara Institute of Science and Technology, Graduate School of Biological Sciences • Kwansei Gakuin University Bioscience Department • Osaka University School of Medicine

13. CDB International Affiliations • The University of Texas Graduate School of Biomedical Sciences at Houston, Texas, USA • Temasek Life Sciences Laboratory Limited, Singapore • National Centre for Biological Sciences, TIFR, Bangalore, India • Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany (from August 2004) • McGill University Faculty of Science, Montreal, Canada • GSF - National Research Center for Environment and Health, Neuherberg, Germany

14. Budget and Staff 2005 Staff: ~550 research, student and administrative staff 2005 Budget: 5.1 billion yen

15. 1F lounge, lecture theatre 2F〜5F labs 6F library, seminar room Kobe Medical Industry Project Research Park CDB Bldg C Kobe Univ. Business Incubation Center 1F mouse facility transgenic/KO lab aquarium 2F mouse facility operation/virus rooms CDB Animal Facility Business Support Center for Biomedical Research and Innovation 1F MRI (3T), open MRI CT-guided irradiation 2F PET 1F operations cafeteria 2F outpatient 3F clinical lab 4F office 5F hospital CDB Bldg B IBRI Medical Imaging IBRI Clinical Bldg 1F mouse/rat facility 2F common-use facility Translational Research Informatics Center IBRI Lab Bldg CDB Bldg A 1F admin office, lobby, EM lab, RI lab 2F PR office, cold room, virus lab 3F〜6F labs 7F labs, seminar room, lounge KIMEC Center 1F rental labs 2F CDB labs（stem cells） 3F CDB labs（stem cells)・FACS room 4F・5F Cell Processing Center Kobe International Business Center

16. RIKEN Research Centers • Tsukuba Institute • Bioresource Center Photodynamics Research Center • Wako Campus • Brain Science Institute • Frontier Research Systems • Accelerator Research Facility • RIKEN Yokohama Institute • Genomic Sciences Center • Plant Science Center • SNP Research Center • Research Center for Allergy and • Immunology • Harima Institute • SPring-8 Bio-Mimetic Control Research Center • Overseas • Rutherford-Appleton Lab • Brookhaven National Lab • RIKEN-MIT Neuroscience Research Center • Kobe Institute • Center for Developmental Biology