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Blood Film

Blood Physiology Lecture -4 White Blood Cells –cont Professor A.M.A Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of Medicine & The Blood Bank, King Khalid University Hospital King Saud University Riyadh. Blood Film.

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Blood Film

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  1. Blood PhysiologyLecture -4White Blood Cells –contProfessor A.M.A Abdel GaderMD, PhD, FRCP (Lond., Edin), FRSH (London)Professor of Physiology, College of Medicine &The Blood Bank, King Khalid University HospitalKing Saud UniversityRiyadh

  2. BloodFilm

  3. White Blood Cells–cont- Agranulocytes – Objectives of the lecture: At the end of this lecture the student should be able to: • Describe monocyte formation and function • Describe the reticuloendothelial system components and function • Describe lymphocyte formation • Describe the functions of the diffrerent types of lymphocytes • Recognize leucocytosis, leucopenia and leukaemia

  4. White Blood Cells –contAgranulocytes Contents: • Monocyte formation, maturation and function • Reticulendothelial system components and function • Lymphocyte formation and function • Leucocytosis, leucopenia and leukaemia

  5. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes 5.3% • 15-20um, kidney shape nucleus • Lymphocyte 30%

  6. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte 30%

  7. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  8. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  9. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  10. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  11. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  12. Defensive Functions of the Monocytes • Directly: • phygocytosis of bacteria, dead cells etc • Indirectly: • Cooperates with lymphocytes by: • Recognizing the foreign body • Ingesting the foreign body • Processing the foreign body • Presenting it to lymphocytes

  13. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  14. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  15. Hemopoiesis (17.9)

  16. Lymphocytes– cont. Lymphopoiesis Stem cell (thymus, lymphoid tissue & bone marrow) lymphoblast intermediate pyronophilic blast cells lymphocytes

  17. Immunity -- Types Acquired immunity: • Basic types of acquired immunity: Humoral immunity (B-cell immunity) B-LYMPHOCYTES Antibodies Cell-mediated immunity (T-cell immunity) Activated T-LYMPHOCYTES Initiated by antigens

  18. The bases of Acquired Immunity are Lymphocytes

  19. Immune cells Two types: • B-Lymphocytes (Thymus independent, B-lymphocytes) Produce antibodies (Humoral Immunity) 2. T- lymphocytes (Thymus dependent, T-lymphocytes) Cellular mechanisms (Cellular Immunity)

  20. Functions of Leucocytes- WBCSummary • Defence of the body against infections and foreign invadors Neutrophils & monocytes (Blood macrophages)-Phgaocytosist/ + Immunity Macrophage (RES) system … Phagocytosis + Immunity Lymphcytes ….. IMMUNITY

  21. White Blood Cells –contAgranulocytes Contents: • Monocyte formation, maturation and function • Reticulendothelial system components and function • Lymphocyte formation and function • Leucocytosis, leucopenia and leukaemia

  22. Leucocytosis(Increased WBC Count) Causes: • Physiological • Diurnal: morning  evening • After physical exercise • Stress or Adrenaline injection • Disease (pathological) • Bacterial infections (tonsillitis, appendicitis • Worms infestations

  23. Leucopenia(Decreased WBC Count) Causes: • Malnutrition • Typhoid fever • Depressed bone marrow • Deficiency of Vit B12 or folic acid

  24. The Macrophage system Reticulo-endothelial System(RES)

  25. Reticuloendothelial System-RES • RES is widespread in the body Cells of the RES: • Monocytes (blood macrophages) • Mobile and fixed tissue Macrophages • Endothelial cells in bone marrow, lymph nodes and spleen • Reticular cells of lymph nodes spleen & bone marrow.

  26. Reticuloendothelial System-RESCells of the RES - Distribution: • Tissue Macrophages in skin SC tissues • Tisssue Macrophages of lymph nodes • Tissue macrophages in lungs • Macrphages (kupffer cells) in the liver • Macrphages in the spleen and bone marrow

  27. Functions of Reticuloendothelial system • Phagocytosis: Bacterial, dead cells, foreign particles • Breakdownof Hb • Immune function: processing antigen and antibodies production (indirect) • Storage of iron Dr Sitelbanat

  28. White Blood Cells –cont- Agranulocytes – Objectives of the lecture: At the end of of this lecture the student should be able to: • Describe monocyte formation and function • Describe the reticuloendothelial system components and function • Describe lymphocyte formation • Describe the functions of the diffrerent types of lymphocytes • Recognize leucocytosis, leucopenia and leukaemia

  29. THANK YOU لكم جزيل الشكر

  30. THANK YOU لكم جزيل الشكر

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