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DNA Polymerase γ B Processivity Factor

DNA Polymerase γ B Processivity Factor. Molecular Cell, Volume 7, Issue 1 , 1 January 2001, Pages 43-54 PDB ID:1G5H. Superpositioning with GRS. Dimerization domain. Four helix-bundle. DNA binding domain. Mutation of DNA bind domain. Modeling structure. PCNA.

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DNA Polymerase γ B Processivity Factor

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  1. DNA PolymeraseγB Processivity Factor Molecular Cell, Volume 7, Issue 1 , 1 January 2001, Pages 43-54 PDB ID:1G5H

  2. Superpositioning with GRS

  3. Dimerization domain

  4. Four helix-bundle

  5. DNA binding domain

  6. Mutation of DNA bind domain

  7. Modeling structure

  8. PCNA

  9. What kinds of DNA will bind to it?

  10. BLASTP 2.2.10

  11. Multiple sequences alignment

  12. Phylogenetic tree

  13. Conclusion • PolγB & Glycyl-tRNA synthetase diverged from early gene duplication • Suggest that eukaryotic Glycyl-tRNA synthetase is from Archaea, PolγB is from Bacterial Glycyl-tRNA synthetase.

  14. 多謝聆聽！

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