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Time (h)

-P-EGFR. -P-ERK1/2. -P-p90 rsk. -P-CREB. -Tubulin. 0 5 10 15 30 60 EGF (100ng/ml) min. 25. A. B. 20. 15. Fold Induction (EGF/Control). 10. 5. 0. 0 1 2 3 4 5 6. -5. Time (h). EGF. EGF+U0126. C. D.

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Time (h)

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  1. -P-EGFR -P-ERK1/2 -P-p90rsk -P-CREB -Tubulin 0 5 10 15 30 60 EGF (100ng/ml) min 25 A. B. 20 15 Fold Induction (EGF/Control) 10 5 0 0 1 2 3 4 5 6 -5 Time (h) EGF EGF+U0126 C. D. -P-ERK1/2 -Cyclin D1 -Cyclin E -p27 Kip1 -Tubulin 0 5’ 6h 24h 5’ 6h 24h

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