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The Global Burden of Multimorbidity. Presented by Sara Afshar, PhD Student for the Population Health Conference “ Tackling Population Health Challenges ” Joint Supervision - Faculty of Medicine & Faculty of Social Sciences
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The Global Burden of Multimorbidity Presented by Sara Afshar, PhD Student for the Population Health Conference “Tackling Population Health Challenges” Joint Supervision - Faculty of Medicine & Faculty of Social Sciences Supervisors: Prof. Paul Roderick, Prof. Allan Hill & Dr. Borislav Dimitrov
Background • Due to demographic and epidemiological transition, there is a greater disease burden from NCDs, paralleled by a rapidly ageing population globally • Although there is no consensus, multimorbidity commonly defined as presence of ≥ 2 chronic diseases within an individual • Multimorbidity is a consequence of human ageing and NCD burden, although relatively understudied, particularly in LMICs • Global morbidity studies largely single-disease focused
In HIC, multimorbidity is: • associated with lower SES (Barnett et al, 2012), • assocated with increased health service utilisation and health expenditure; poorer health outcomes and quality of life; reduced functional capacity; and decreased survival • described as the ‘norm rather than the exception’ – majority of patients attending primary care >65 have MM
Prevalence of Multimorbidity by age and socioeconomic statusSource: Barnett et al. Lancet (2012)
Aims To compare the prevalence of multimorbidity across LMIC and HIC, and by age and SES (defined by education) • Examining inter and intra country differences, • how does multimorbidity prevalence vary across income group and within countries , respectively using GDP per capita and SES (education)? • how does multimorbidity prevalence vary across age groups?
Methods • Data taken from the World Health Surveys (WHS) and Wave 1 of English Longitudinal Survey of Aging (ELSA) • WHS: a cross-sectional national survey, uses multi-stage clustering design to produce nationally representative samples; ages >18 years, 2003 • ELSA: a longitudinal survey of 11,500 people in England >50 years, multistage clustering design. Wave 1, 2003. • Multimorbidity defined as the presence of 2 or more of following doctor diagnosed conditions (n=6): arthritis, angina, asthma, diabetes, depression and schizophrenia
Methods • Countries selected to represent all regions of the world with specific focus on middle-income countries • Countries excluded if RR to chronic disease questions <90% • Survey weights and post-stratification corrections applied to produce nationally representative samples • Age adjusted prevalence directly standardised to WHO Standard Population • Individual countries weighted by survey size to produce regional estimates for MM by SES (education)
Multimorbidity/ % GDP, per capita Figure 1 : World Standardised Multimorbidity Prevalence by GDP across World Health Survey Countries (n=28) in 2003; with confidence intervals Notes:a) GDP are based on those provided by United Nations Statistical Division for 2003 estimates b) National Estimates have been adjusted to the WHO Standard Population Distribution (2000-2025) c) Human Development grouping based on Human Development Report estimates for 2003
Results Figure 2: Age specific multimorbidity prevalence across World Health Survey Countries (n=28) in 2003 and the English Longitudinal Survey of Ageing (ELSA)
Figure 3: Regionalmultimorbidity by socioeconomic status (education) Prevalence ratios for ≥ 55 years Prevalence ratios for < 55 years Notes:a) Lightest shade represents first category (secondary education achieved); darkest shade represents final category (less than primary school education achieved) b) Multimorbidity Prevalence ratios based on prevalence of multimorbidity in second category set at 1.
Discussion • Implications for future is that LMIC is transitioning towards a HIC pattern; as younger generations age, there will be a higher burden in elderly population Limitations • Limited set of conditions in WHS; evidence from ELSA shows that increasing the number of conditions increases MM prevalence • Low response rate in low income countries means not represented • Doctor diagnosed conditions may be correlated to greater health access, although lower prevalence in Spain and England suggest more complex story
Conclusion • Multimorbidity a global phenomenon and not just affecting older adults in HIC • Evidence of a MM transition in LMIC with increased multimorbidity prevalence, particularly for young adults in LMIC: suggests a change in lifestyle and accumulation of risk for NCDS • Implications for health care provision, planning, policy and public health intervention.