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4. 15/06/2018 Buy Duovir-N Tablets | AllDayGeneric.com - My Online Generic Store • Lamivudine 150mg belongs to a class of medica?on called nucleoside reverse transcriptase inhibitors. It decreases the amount of virus (HIV and hepa??s) in the blood. It also increases the number of infec?on figh?ng cells in the body (CD4 cells). It does not cure HIV completely but reduces the chances of ge?ng acquired immunodeficiency syndrome (AIDS) and HIV related infec?ons or cancer. • Zidovudine 300mg belongs to a group of medica?ons called nucleoside analogue reverse transcriptase inhibitors (NRTIs), also known as an?retrovirals. Zidovudine does not cure HIV infec?on; it reduces the amount of viruses in the body by inhibi?ng the enzyme (viral reverse transcriptase) which is essen?al for the virus to grow. Further, zidovudine also increases some white blood cells (CD4 cells) of the body that are important in figh?ng infec?ons. • Nevirapine 200mg belongs to a class of an?-HIV medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs). Reverse transcriptase is an enzyme that HIV needs in order to mul?ply. Nevirapine stops reverse transcriptase from working, and thus helps control HIV-1 infec?on. Common side effects Diarrhea and fever, Redistribu?on/accumula?on of body fat, Acne-like rash, Depression, Arthralgia, Increase in blood urea or crea?ne phosphokinase, Dizziness, Insomnia, Cough, Fa?gue and malaise, Abdominal cramps, Anorexia and stoma??s, Thrombocytopenia, Worsening of hepa??s b infec?on, Myalgia, Amylase, Peripheral neuropathy, Musculoskeletal pain, Chills, Neuropathy, Abdominal pain, Neutropenia, Dyspepsia, Pancrea??s, Andheadache How should Duovir-N be taken? You should take your Duovir-N tablets, 1 tablet twice daily, with a glass of water, with or without food. Since each tablet of Duovir-N contains half of the commonly prescribed daily doses of each of the 3 cons?tuent drug, zidovudine, lamivudine and nevirapine, you should not need to change the dose of Duovir-N. You should con?nue to take your Duovir-N for as long as recommended by your doctor, and you will be monitored carefully to ensure that you do not develop any serious side effects, in which case your doctor will probably recommend that you stop taking your Duovir-N tablets. How long should you take Duovir-N? You should take your Duovir-N tablets con?nually for as long as recommended by your doctor, and you will be monitored carefully to ensure that you do not develop any serious side effects, in which case your doctor will probably recommend that you stop taking your Duovir-N tablets. Missed dose of Duovir-N If you miss a dose of Duovir-N take it as soon as you remember, unless it is ?me to take the next dose, then skip the missed dose. Do not take a double dose. How should Duovir-N be stored? https://www.alldaygeneric.com/product/duovir-n-tablets/ 4/9

5. 15/06/2018 Buy Duovir-N Tablets | AllDayGeneric.com - My Online Generic Store You keep your Duovir-N tablets below 30°C in a cool dry place. EXPERT ADVICE • Consult your doctor if you have diabetes and are using insulin. • Pa?ents receiving this therapy are always at a risk for infec?ons and hence should report any such cases to the doctor. • Consult your doctor if you take any prescrip?on medica?on; Inform your doctor if you take other medicine for treatment of HIV or hepa??s B infec?on, hairy cell leukemia [a type of blood cancer], or an?bio?cs for infec?on. • Lamivudine may rarely cause a serious side effect like lac?c acidosis with symptoms such as pain or weakness of muscle, numbness or feeling cold in arms or legs, stomach pain, nausea, vomi?ng, lack of breath, aberrant heart rate, dizziness, weak or ?red feeling; hence, inform the doctor immediately if you experience any of these symptoms. • It is possible to pass on HIV when on this medica?on and hence it is important to take necessary precau?ons to prevent HIV from spreading. • Inform you doctor if you no?ce signs of change in the distribu?on of fat (lipodystrophy), erosion of bones (osteronecrosis), or inflamma?on of pancreas (pancrea??s). • If you are on therapy it is important to use effec?ve non hormonal method of contracep?on or condom so that a pregnancy can be avoided. • Use with cau?on in pediatric pa?ents with a history of pancrea??s or other significant risk factors for pancrea??s. FREQUENTLY ASKED QUESTIONS Lamivudine Q. Is lamivudine safe during pregnancy? Lamivudine can be taken during pregnancy if the benefit outweighs the risk. Q. Is it safe to use lamivudine during breas?eeding? HIV infected women should not breas?eed for the risk of passing the virus to the baby through the breast milk. Q. Can lamivudine cure hepa??s B? Lamivudine is used to treat hepa??s B but some pa?ents may be resistant to this drug Q. Can lamivudine cause anemia? Lamivudine may cause anemia as a side effect in some pa?ents. Kindly consult your doctor in case any side effects are observed. Zidovudine Q. Is zidovudine safe during pregnancy? Zidovudine may harm the baby. Zidovudine should only be given if there is no other alterna?ve drug. Please follow your doctor’s advice regarding its use. Q. Is it safe to use zidovudine during breas?eeding? Zidovudine is not safe for the baby and should not be used by women who are breas?eeding. https://www.alldaygeneric.com/product/duovir-n-tablets/ 5/9

6. 15/06/2018 Buy Duovir-N Tablets | AllDayGeneric.com - My Online Generic Store Q. Is zidovudine a prodrug? Yes, zidovudine is a prodrug and must be ac?vated (by phosphoryla?on in lymphocytes) in the body to exert its an?viral ac?on. Q. Is zidovudine a protease inhibitor? No, zidovudine is not a protease inhibitor; it is a nucleoside analogue reverse transcriptase inhibitor. Q. Does zidovudine cross placenta? Zidovudine crosses placenta and thereby reducing the HIV transmission from the mother to the fetus. Q. How is zidovudine administered? Zidovudine can be administered as tablets, syrups and suspension in combina?on with other an?retroviral medica?ons. Q. Does zidovudine cause muscle pain? Yes, muscle pain is a known adverse effect of use zidovudine. Nevirapine Q. Is nevirapine the same as Viramune? Yes, Viramune is a brand name of nevirapine. Q. Is nevirapine safe in pregnancy? Experiences of drug use and evidence from studies in pregnant women have shown risk to fetus. This drug may be used in pregnant women if benefit outweighs the risk. Pa?ents should follow the advice of the doctor regarding its use. Q. Is nevirapine generic? Nevirapine is a generic drug. Related Products (h?ps://www.alldaygeneric.com/product/lopimune- tablets/) (h?ps://www.alldaygeneric.com/product/acivir- cream/) (h?ps://www.alldaygeneric.com/produ tablets/) ( Lopimune Tablets (H?ps://Www.Alldaygeneric.Com/Product/Lopimune- Tablets/) Acivir Cream (H?ps://Www.Alldaygeneric.Com/Product/Acivir- Cream/) Duovir Tablets (H?ps://Www.Alldaygeneric. Tablets/) ( Generic Name : Lopinavir + Ritonavir Generic Name : Acyclovir Generic for : Zovirax Cream Generic Name : Lamivudine + Zidovudine https://www.alldaygeneric.com/product/duovir-n-tablets/ 6/9

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