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Research Update: Mechanisms for Control and Regulation of the AQP-4 Network

Research Update: Mechanisms for Control and Regulation of the AQP-4 Network. Minh Tran LPPD Mentor: Ying Hsu Advisor: Prof. Andreas Linninger Feb. 8, 2012. Control Mechanisms applicable to protein regulation networks. Block diagram for temperature feedback control system.

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Research Update: Mechanisms for Control and Regulation of the AQP-4 Network

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  1. Research Update:Mechanisms for Control and Regulation of the AQP-4 Network Minh Tran LPPD Mentor: Ying Hsu Advisor: Prof. Andreas Linninger Feb. 8, 2012

  2. Control Mechanisms applicable to protein regulation networks Block diagram for temperature feedback control system

  3. Previous AQP-4 Network Jared Wedell F’11 Osmotic stress Transcription initiation Transcription DNA mRNA Translation mRNA aquaporin channel

  4. Updated AQP-4 Network:implementation of control loops Cytoplasm PKC activator Nucleus Functional AQP-4 Translation P38 MAPK stimulation by Osmotic stress Transcription Translation pre-Transcription

  5. Protein Control within a Cell:negative feedback Negative Feedback Negative Feedback PKC activator Transcriptional Dynamic State Downregulates AQP-4 mRNA Translational Steady State Downregulates AQP-4 mRNA

  6. variations of p38 can either upregulate or downregulate transcription • P38 is a stress-induced osmotic pathway. • P38α • Known to phosporylate Activator Factor 1 (AP-1) • Activated by osmotic stress. • P38γ • Known to repress Activation Factor 1 (AP-1) • Strongly activated by Hypoxia (lack of oxygen)

  7. Upcoming tasks • Edit Jared’s Cell Network paper • Perform simulations of AQP-4 Network using • CellDesigner • MATLAB • Input additional regulatory loops into updated AQP-4 Network.

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