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Chapters 8 & 18: Metabolism and Movement of Lipids

Chapters 8 & 18: Metabolism and Movement of Lipids. What types of fats are needed for cell function? Where are each of these types of fats manufactured? How do phospholipids in the outer leaflet of the plasma membrane get there? How do lipids move from place to place in the cell?

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Chapters 8 & 18: Metabolism and Movement of Lipids

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  1. Chapters 8 & 18: Metabolism and Movement of Lipids What types of fats are needed for cell function? Where are each of these types of fats manufactured? How do phospholipids in the outer leaflet of the plasma membrane get there? How do lipids move from place to place in the cell? Where is cholesterol made? What are lipoproteins? How is lipid metabolism regulated? How does imbalance in lipid metabolism contribute to atherosclerosis, heart attacks, and strokes?

  2. What types of fats are needed for cell function?

  3. Fatty Acid Synthesis and Transport

  4. Acetyl coA carboxylase

  5. Acetyl CoA carboxylase catalyzes the reaction: • acetyl CoA + HCO3- + ATP -> malonyl CoA + ADP + Pi • Six molecules of malonyl CoA and one molecule of acetyl CoA then interact sequentially with fatty acid synthase to yield the final product, palmitate.

  6. ER cytosol ER

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