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Incidence of allo-antibodies in servicemen

Incidence of allo-antibodies in servicemen. B. Clavier 1 , S. Ausset 2 , P. Gerome 3 , A.V. Deshayes 1 , A. Sailliol 1 1 French Army transfusion center R.Batany. Clamart, France 2 Percy military hospital. Clamart, France 3 Desgenettes military hospital. Lyon, France. Background.

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Incidence of allo-antibodies in servicemen

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  1. Incidence of allo-antibodies in servicemen B. Clavier1,S. Ausset2, P. Gerome3, A.V. Deshayes1, A. Sailliol1 1French Army transfusion center R.Batany. Clamart, France 2Percy military hospital. Clamart, France 3Desgenettes military hospital. Lyon, France

  2. Background • The incidence of irregular allo-antibodies (IAA) against red blood cells (RBC) in general population is unknown. • The question is relevant during overseas military operations since RBC are transfused without awareness of the presence of such antibodies, so that one asks if a IAA screening should be conducted in every servicemen before overseas operations.

  3. Methods • A research of IAA was performed in all blood donations in the French armies national blood bank during the year 2007. • The incidence IAA was analysed according to age and gender of donors

  4. Results (1) 17 784 donations 44 IAA + IAA clinically relevant:11 (11 donors)mean age 32 (21-47) No incidence on transfusion policy: 33/44 6.2/10 000 (CI 95% : 3.1 –11/10 000) 8 women 3 men 14.5/10 000 2.4/10 000 p=0.0001

  5. Results (2) • anti-RHD (anti-RH1) 4/11anti-E (anti-RH3) 7/11anti-c (anti-RH4) 2/11anti-S (anti-MNS3) 1/11 • Three women had two different antibodies for each: anti-D+E or anti-E+c or anti-c+S • Anti-E antibodies identified in men are natural antibodies probably without risk of adverse reaction.

  6. Conclusion • According to these data (rarity of relevant antibodies and low benefit/risk ratio) the French army medical service has chosen to not perform mandatory IAA screening for servicemen

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