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Improving translation of research into policy and practice: how can the CBIG Program contribute Professor Jeffrey Br

Australian Institute of Health Innovation's mission . Our mission is to enhance local, institutional and international health system decision-making through evidence; and use systems sciences and translational approaches to provide innovative, evidence-based solutions to specified health care deliv

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Improving translation of research into policy and practice: how can the CBIG Program contribute Professor Jeffrey Br

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    1. Improving translation of research into policy and practice: how can the CBIG Program contribute? Professor Jeffrey Braithwaite NSW Health � Capacity Building Infrastructure Grants Forum 24 March 2011, Sydney, Australia

    2. Australian Institute of Health Innovation�s mission Our mission is to enhance local, institutional and international health system decision-making through evidence; and use systems sciences and translational approaches to provide innovative, evidence-based solutions to specified health care delivery problems. 2

    3. Australian Institute of Health Innovation Professor Jeffrey Braithwaite Professor and Foundation Director, AIHI; Director, Centre for Clinical Governance Research Professor Enrico Coiera Professor of Health Informatics, Centre for Health Informatics, AIHI, UNSW Professor Ken Hillman Professor of Intensive Care, Simpson Centre for Health Services Research, AIHI, UNSW Professor Johanna Westbrook Professor of Health Information Centre for Health Systems and Safety Research, AIHI, UNSW 3

    4. NSW Health priorities and targets 4

    5. NSW Health priorities and targets 5

    6. Visions and goals of the NSW public health system 6

    7. Centre for Health Informatics 7

    8. Simpson Centre 8

    9. Centre for Clinical Governance Research 9

    10. Centre for Health Systems and Safety Research 10

    11. Current grants 11

    12. Current grants 12

    13. Current grants 13

    14. Current grants 14

    15. CBIG research projects 15

    16. Nurse Decision Making and the Deteriorating Patient 16

    17. Modelling the Medical Emergency Team (MET) system 17

    18. Modelling the Medical Emergency Team (MET) system and their cultural and environmental settings 18

    19. Understanding Antibiotic Resistant Strains Strains of bacteria that are simultaneously resistant to multiple types of antibiotics are on the rise and already cost $2.5B p.a. in Australia The DNA of bacteria has the �instructions� that bacteria has to follow to survive including how to resist antibiotics Complex genetic mechanisms allow individual bacteria to �learn� from each other (even across species) by sharing DNA 19 Excess costs come from cases where an antibiotic was given and was later thought to be resistant leading to excess stay (2 days on average) and often an increase in mortality (up to 30%) Excess costs come from cases where an antibiotic was given and was later thought to be resistant leading to excess stay (2 days on average) and often an increase in mortality (up to 30%)

    20. Resistance sharing models We developed models of complex mechanisms for transferring genes in DNA. With them we can: Monitor and survey the spread of resistance from individual wards to internationally Offer tools to the scientists community to help them understand their isolates (through RAC) Interpret DNA to understand evolution and biological mechanisms 20

    21. Is DNA a language? Used for communication Hierarchical: Subject to evolutionary development Uses ambiguities and contexts to convey complex ideas 21

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