Probiotics

1. Probiotics A Possible Answer To Decreasing Immune System Health

2. Digestive Problems Nationally • $107 billion in direct health care expenditures in 1992. • 200 million sick days, 50 million physician visits, 16.9 million school days lost, 10 million hospitalizations, & almost 200,000 deaths per year. • Digestive tract cancers are responsible for 117,000 deaths/yr, & non-cancerous digestive diseases cause 74,000 deaths/yr.

3. Background • Quality of an individual’s immune system can be evaluated through the Th1/Th2 balance: • Th1=Cops Th2=Armed Forces • A healthy immune system is balanced and dynamic, switching back and forth as needed. • Inadequate Th1 response can result in chronic infection, chronic fatigue syndrome & cancer. • Overactive (but paradoxically ineffective) Th2 response can contribute to allergies and syndromes and have a role in autoimmune disease. • Combination of failure of Th1 and overactive, but ineffective, Th2, are seen in a wide variety of chronic illnesses: AIDS, chronic fatigue syndrome, candidiasis, multiple allergies, viral hepatitis, cancer, lupus, and many others.

4. Theory • If the two arms of the immune system can be balanced by stimulating Th1 cells and decreasing Th2 cells, then many symptoms of theses illnesses would diminish or disappear. • With adequate exposure to viruses, bacteria, and microorganisms, our Th cells mature in proper proportion into Th1 cells, but without enough exposure our cells are prone to overreactions and likely to mature into Th2 cells.

5. Dysbiosis • Dysbiosis is an intestinal imbalance where pathogenic microorganisms outnumber beneficial bacterial species. • Digestive diseases are often caused in part by or result in dysbiosis.

6. Early Development

7. Dysbiosis Major Causes

8. Dysbiosis Common Symptoms

9. Why should YOU care? • Chemical farming and pesticides have lead to sterilization of soil and water (chlorination). • Antibiotics, hormones, and other drugs are given to chickens and cattle used for food. • Stress, medications, and typical American diet all promote dysbiosis.

10. What MORE do we know? • Probiotics are live active cultures that are supposed to improve the balance of the gut microbiota, with specific effects, in particular, the immunomodulatory potential of specific strains. • The strains with the most beneficial properties, potential sources of probiotics, belong most frequently to the genera Bifidobacterium and Lactobacillus.

11. Special Probiotics • Homeostatic Soil Organisms (HSO’s) are specific probiotic strains of microorganisms found in the soil. • In nature, HSO’s help plants digest inorganic substances, protect roots from parasites, yeast, and fungi, and provide growth factors and different hormones. • When ingested orally in a probiotic formulation, may have advantages over non-HSO probiotic formulas, due to ability to implant and survive in the gut.

12. The Researcher • A Natural Hygiene Practitioner and a University Professor of Gastroenterology, Rheumatology, and Clinical Nutrition since 1979, Dr. Goldberg has long been devoted to helping others reverse chronic illnesses through Natural Hygienic/Biological Measures. PAUL GOLDBERG, M.P.H., D.C.Natural Hygiene Practitioner, Professor, Educator, and Researcher.

13. The Study Background: A theory known as the “hygiene hypothesis,” suggests that many people in modern societies have been too highly protected from normal bacteria. This isolation from the bacteria in our environment, according to the hygiene hypothesis may contribute to the rise in chronic degenerative diseases such as asthma, inflammatory bowel diseases, and a host of allergic conditions.

14. The Study Hypothesis: Anecdotal evidence suggests that a variety of gastrointestinal, allergic, autoimmune, and degenerative conditions, can be affected positively by the consistent (3 months or longer) administration of an HSO formulation. This pilot study was undertaken to explore the possible advantages of clinical responses in subjects with a variety of medically unresponsive chronic disease conditions of at least 3 years duration.

15. The Study Subject Selection Criteria: • Had a medically diagnosed chronic condition. • Had condition for at least 3 yrs (mean of 5.5 yrs) • Condition did not positively respond to medical intervention. • 18 years old or older • Not currently taking any corticosteroids, antibiotics, or other drugs that might mask study outcome. • Agreed to follow study protocol for 120 days. • Undergo case history/physical examination and have following blood tests: a)Blood Chemistry, b)Complete Blood Count with Differential, c) Blood Lipids • Required to provide stool sample pre and post-study for microbiological analysis including bacteriology and mycology. • No cases accepted who ingested alcohol beyond 2 drinks a week, tobacco in any form or amount, or any other recreational drug use for a period of not less than 60 days prior to the study.

16. The Study Protocol Subjects took 18 caplets of Primal Defense HSOs per day for 120 days with following instructions: • Take 6 caplets 3x a day on empty stomach with 8 ounces of water. • Drink sufficient water • Take adequate care of general health, by avoiding processed foods, getting sufficient rest and sleep, and not engaging in toxic habits, specifically alcohol, tobacco, or any other drugs other than needed prescription medications.

17. Results

18. Results • 16 of 17 subjects completing study reported improvements in their symptoms, including: • partial to complete relief from bowel problems • decreases in asthmatic symptomology • increases in energy levels • improvements in skin conditions • improvement in chronic sinus infection • general improvements in overall well-being. • No subjects reported any worsening of symptoms at completion of study.

19. What does it mean? • The HSOs work in a similar way in the human intestinal tract as they do with plants, providing a line of defense as well as growth factors and nutrients, which together result in overall increased health. • HSOs are able to implant and survive well in the gut.

20. Are the findings credible? • The testing methods and findings both are backed by numerous other similar clinical tests done for specific problems or diseases using HSOs. • Suspect point: Were diet and other restrictions actually responsible for results more than HSOs?

21. Further Research • High cholesterol study • Energy levels, memory and concentration study • Chronic Lymphcytic Leukemia stage II study

22. More on HSOs • HSOs Pool New RNA/DNA in the Cells • HSOs Quench Free Radicals by Creating SOD • HSOs Stimulate Alpha Interferon Production • HSOs Stimulate the Production of Human Lactoferrin

23. Further Reading • The reduction of Candida albicans "yeast" overgrowth using Fungal Defense and Primal Defense along with lifestyle modifications a 23 patient pilot study. • Complementary treatment of Chronic Digestive Disorders with Malabsorption Syndrome using HSOs. • Portal to the interior: viral pathogenesis and natural compounds that restore mucosal immunity and modulate inflammation.

24. Sources • Patient Heal Thyself by Jordan S. Rubin • “Probiotics” by Erik Isolauri, Seppo Salminen, Arthur C. Ouwehand, from Best Practice and Research Clinical Gastrointerology Vol. 18, No. 2, pp. 299-313, 2004. • “Homeostatic Soil Organisms as a Treatment for Chronic Disease Conditions—A Pilot Study” by Dr. Paul Goldberg