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About This Slide Set. The Introduction to Clinical Osteoporosis slide set is a unique educational resource developed by IBMS BoneKEy with the help of leading clinicians and researchers in the bone field. Covering the epidemiology, pathophysiology, genetics, diagnosis, and treatment of osteoporosis, the slide set offers a comprehensive overview of current knowledge about osteoporosis, a disease with an enormous global health impact. The slide set is supported by an unrestricted educational gra9446
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3. Definition of Osteoporosis • A skeletal disorder characterized by
compromised bone strength predisposing to
an increased risk of fracture.
• Bone strength reflects the integration
of two main features:
bone density and
bone quality.
This definition of osteoporosis emphasizes that the density and quality of bone are distinct properties. Bone density can be quantified; bone quality is not directly quantifiable. Bone quality is determined by the material properties of bone, its microarchitecture, its geometry, and its rate of turnover.
This definition of osteoporosis emphasizes that the density and quality of bone are distinct properties. Bone density can be quantified; bone quality is not directly quantifiable. Bone quality is determined by the material properties of bone, its microarchitecture, its geometry, and its rate of turnover.