C L A

1. C L A Conjugated Linoleic Acid Alexis Lemmex, Katelin Rorabeck, Sheila Kelly

2. Outline • What is it? • Scientific background • Physiological affects • Side effects • Case Studies • Retail and Marketing • Conclusion

3. Did you know??? • There was over 10,000 deaths in NA (10,271 to be exact) from heart disease, diabetes, stroke, fatty liver disease, blood clots, hearts attacks and a host of other obesity-caused illnesses in overweight/obese patients, in 2004 alone!

4. In Canada, 36% of teenagers are overweight or obese. 59% of adults in Canada are overweight/obese. • 2.4 % Canadian teenage girls between the ages of 12 to 18 are using diet pills.

5. What is it • Isomer of omega-6 essential fatty acid • Refers to a family of 8 geometric isomers of linoleic acid • Found in meat and dairy products

6. Lets Talk Science • CLA is an isomer of Linoleic Acid • CLA isomers have conjugated bonds Linoleic acid Trans 9- cis 11, octadecadienoic acid Trans 10- cis 12, octadecadienoic acid • Principal dietary isomer of CLA • Found in the stomach of ruminant animals • Anti-cancerous • Also found in the stomach of ruminant animals • More effective in reducing body weight

7. Where is it Found? • Milk • Ruminant meats • Poultry • Eggs • Dairy products like cheese and yogurt • Processed Foods like Cheez Whiz

8. Physiological Effects • CLA occurs naturally in whole meats and whole milk (5mm per gram of fat) • Always consider the effects of both isomers ( cis 9, trans 11 and trans 10, cis 12) • At least 8 different CLA isomers to have different physiological effect on health benefit

9. Overview of Physiological Effects • Weight Loss/ Lean tissue builder • Cancer fighting effects • Effect on diabetics

10. Weight Loss / Lean tissue builder • CLA may: • reduce percent body fat • Reduces leptin (enzyme associated with appetite) • Promote apoptosis of adipose tissue • Interferes with Lipoprotein lipase

11. Effects of Leptin

12. Inhibits tumor growth • Inhibit the proliferation of tumor growth • Role in blocking the growth of tissue that support cancer • Some isomers exhibit an inhibitory effect on cancer prevention

13. Side Effects • Fairly new • Studies have shown it increases LDL’s

14. Case Study #1 The Effects of CLA and Exercise on Mice • 8 week old mice divided into 2 dietary groups and feed the same diet • Each dietary group was divided into sedentary and exercise groups • Mice were exercised 5 days a week for 14 weeks, gradually increasing the speed and duration

15. Case Study #1 con’t Results: • All groups gained weight during the first 6 weeks of the study • Non- CLA exercise group decreased weight • CLA exercise and sedentary groups gained less weight • CLA exercise but not CLA sedentary had greatest gain in lean body mass • Suggests the consumption of CLA in diet combined with moderate exercise can decrease gain in total body fat and increase lean body mass more than exercise alone

16. Case Study #2 • Random • Double-blind • Placebo controlled (hydrogel) • 20 healthy people • Exercised 90 mins, 3 times/wk • Placebo or 0.6mg of CLA 3 times/day • 2 capsules/meal • 12 weeks

17. Case Study #2 con’t • Body fat, measured using near infrared light, was significantly reduced in the CLA group but not in the placebo group • Reduces body fat, NOT weight Results:

18. How Much?

19. Retail Value • Herbal Select Conjugated Linoleic Acid • 1000mg • 90 caps $21.24 CAD • Herbal Select Conjugated Linoleic Acid • 1000mg • 60 softgels $15.00 CAD

20. Marketing

21. WEIGHT MANAGEMENT & MORE • Promotes healthy body composition • Supports a healthy inflammation response • Enhances immune function • Provides antioxidant protection • Use as part of a healthy diet and exercise program

22. Marketing • “All-natural Multi-faceted Nutrient” • “Derived from the oils of the safflower”

23. Marketing • Overweight people • Body Builders • Athletes

24. Conclusion Summary Our 2 cents Facts Broad Statement

25. Questions Anyone?