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Vincent is off colour

Vincent is off colour. Case Summary. Anatomy - abdominal cavity. Peritoneum Mesentery Intraperitoneal organs Retroperiotoneal organs. Anatomy – anterior abdo wall. Anatomy of the liver. Basic embryology of the GIT. Anatomy - abdominal cavity. Functions of the liver. Metabolism

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Vincent is off colour

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  1. Vincent is off colour

  2. Case Summary

  3. Anatomy - abdominal cavity • Peritoneum • Mesentery • Intraperitoneal organs • Retroperiotoneal organs

  4. Anatomy – anterior abdo wall

  5. Anatomy of the liver

  6. Basic embryology of the GIT

  7. Anatomy - abdominal cavity

  8. Functions of the liver • Metabolism • Carbs • Proteins • Fats • Hormones • Detoxification of drugs, toxins, waste products • Storage of glycogen, iron and vitamins • Production of plasma proteins and clotting factors • Bile formation / RBC turnover • Haematopoiesis (foetal) • Immunological (reticuloendothelial cells) • Vitamin D activation • Storage of blood

  9. Histology of the liver

  10. Histology of the liver

  11. Histology quiz • Draw a classic hepatic lobule • Draw a hepatic acinusand briefly outline the zones • What are the 3 different surfaces of hepatocytes? • What is contained in a portal tract? • Outline how blood from the systemic circulation gets to the hepatic lobule/acinus • Outline how blood from the portal circulation gets to the hepatic lobule/acinus • Outline how blood leaves the hepatic lobule and returns to the heart? • Outline the flow of bile from the liver lobule

  12. Histology of the liver

  13. Histology of the liver http://www.ouhsc.edu/histology/

  14. Histology of the liver http://www.medicalschoolpathology.com/

  15. Bilirubin metabolism • Senescent RBCs (~120 days lifespan) rupture and the released haemoglobin is metabolised by tissue macrophages • Team of 2 to draw a diagram of bilirubin metabolism / haem catabolism

  16. Jaundice • What is it? • What else is it called? • What are the causes?

  17. Jaundice • What is it? • What else is it called? • What are the causes?

  18. LFT’s • ALT • AST • ALP • GGT

  19. Viruses

  20. Antivirals

  21. Hepatitis

  22. Hepatitis viral serology

  23. Notifiable diseases

  24. Surface anatomy - abdomen

  25. Examination of the gastrointestinal system

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