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Projekt FLARE

Projekt FLARE Rolle von Flammschutzmitteln als endokrin aktive Substanzen in der Umwelt (NFP50: Hormonaktive Stoffe: Bedeutung für Menschen, Tiere und Ökosysteme) Partner SAFE (Patricia Holm) PHEBRO (Walter Giger und Hans Peter Kohler) Umsetzung Zeithorizont: Frühjahr 2003

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Projekt FLARE

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  1. Projekt FLARE • Rolle von Flammschutzmitteln als endokrin aktive Substanzen in der Umwelt (NFP50: Hormonaktive Stoffe: Bedeutung für Menschen, Tiere und Ökosysteme) • Partner • SAFE (Patricia Holm) • PHEBRO (Walter Giger und Hans Peter Kohler) • Umsetzung • Zeithorizont: Frühjahr 2003 • Finden von Hotspots (Projekte SAFE / Fischnetz) • endokrine Aktivität des Flusswassers (YEAST) • erhöhte Vitellogenin Levels Bachforellen • Analyse von Leber/Galle von Bachforellen • Identifizierung von Metaboliten von bromierten Flammschutzmitteln

  2. FLAREBrominated flame retardants and their transformation products:Occurrence in the environment and human exposure to these endocrine active components • Andreas Gerecke, Peter Schmid, Martin Kohler,Swiss Federal Laboratories for Materials Testing and Research (EMPA), 8600 Dübendorf

  3. Brominated Flame Retardants • Technical Properties • BFR are additives for plastics and textiles (%-range!) • BFR inhibit / suppress combustion • BFR are now the second most used additive for plastics • Annual production over 150,000 tons, demand increasing • Environmental Impact -Is the PCB disaster being repeated? • Some BFR and their metabolites are endocrine disruptors • Some BFR are proven to be persistent organic pollutants (POPs) • BFR in human milk rose from < 1 ng/g lipid to 200 ng/g lipid (USA)

  4. Brominated Flame Retardants • Polybrominated Diphenylethers • Plastics and textiles - persistent organic pollutants • PentaBDE to be banned, DecaBDE as alternative? • Tetrabromobisphenol A • Electronic circuit boards - covalently bound • Similar structure to bisphenol A and T3/T4 • Hexabromocyclododecane • Polystyrene foam and expanded polystyrene • Little is known on fate and toxicity

  5. Endocrine Disrupting Effects • Known Effects of Brominated Flame Retardants • Endocrine disrupting effects found for TBBPA, PBDE and metabolites • PBDE & metabolites are ER alpha and ER beta receptor agonists • PBDE & TBBPA: competition with thyroxine T3/T4 • Immunotoxic effects (reduced production of IgG by BDE-47) • Developmental toxicity (behavior aberration in mice by BDE-99) • Most data available for mammals & assays / little known about fish Transformation products of BDE-199 mimicking T3/T4

  6. Goals and Tasks • Goals • Investigate environmental levels and transformation products of brominated flame retardants in the aquatic environment • Implementation of an effect driven approach - analysing fish & environment where effects of ED are found • Task I • Development of analytical methods for BFR &transformation products • Task II • Collecting and analysing relevant samples for the targetcompounds and for transformation products • Task III • Correlation to effects and implementation of the results

  7. Partners • SAFE • Endocrine disruption in Switzerland: Assessment of fish exposure and effects (SAFE): Patricia Holm, Helmut Segner, Armin Peter • PHEBRO • Phenolic and brominated contaminants in wastewater and in the aquatic environment (PHEBRO): Walter Giger, Hans-Peter Kohler • Aquanet & various Institutions • EAWAG, BAG, BUWAL, FAW • Related Activities at EMPA • Dioxins, coplanar PCB and BFR in various matrices: Markus Zennegg • Brominated flame retardants (BFR) - Transfer from Building Materials and Textiles to Indoor Air and Human Exposure Assessment

  8. Thank you for your attention

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