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Slamf1 -/- [ BALB/c.129]

Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S1A. 4000. 3000. Slamf1 -/- [ BALB/c.129]. 2000. wt BALB/c. 1000. IgM IgG1 IgG2a IgG2b IgG3 IgA. 1000. Slamf2 -/- [ BALB/c.129]. 750. wt BALB/c. 500. 250. IgM IgG1 IgG2a IgG2b IgG3 IgA.

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Slamf1 -/- [ BALB/c.129]

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  1. Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S1A 4000 3000 Slamf1-/- [BALB/c.129] 2000 wt BALB/c 1000 IgM IgG1 IgG2a IgG2b IgG3 IgA 1000 Slamf2-/- [BALB/c.129] 750 wt BALB/c 500 250 IgM IgG1 IgG2a IgG2b IgG3 IgA

  2. Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S1B IgM ¯ 2000 ¯ 1500 1000 500 Slamf1-/- [B6.129] 1 mo 2 mo 3 mo 6 mo wt B6 IgG1 1000 ¯ 750 ¯ 500 250 1 mo 2 mo 3 mo 6 mo

  3. Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S2 100 75 % autoantibody + 50 25 0 F M

  4. Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S3 15.6 84.4 99.3 0.71 99 1.03 98.8 1.25 99.7 0.3 29 71 6.42 93.6 27.4 72.6 B6 Slamf1/- [B6.129] Slamf2-/- [B6.129] Sle1b aSlamf Haplotype 1 aSlamf Haplotype 2 CD244

  5. Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S4 CD4-PE + PNA-FITC CD4-PE + B220-FITC wt BALB/c Slamf1-/- [BALB/c.129] Slamf2-/- [BALB/c.129]

  6. Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S5A p < 0.001 Slamf2-/- [B6.129] Slamf2-/- [B6.129] B6 B6 3 months 6 months

  7. Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S5B Slamf2-/- [B6.129] Slamf2-/- [B6.129] B6 B6 3 months 6 months

  8. Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S6 129/NZW allele D1Mit113 (SLAM locus) B6 allele recombinant region D1Mit149 D1Mit494 D1Mit15 D1Mit105 D1Mit115 D1Mit407 D1Mit223 Slamf2-/- [B6.129] B6.129chr1b (26) B6.Sle1b (13) 10Mb

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