Kobayakawa S. : cova@med.toho-u.ac.jp

1. PEA+Silicone IOL E. faecalis (106 CFU/eye) rabbit GFLX MFLX 8.00 8.00 6.00 6.00 log CFU/ml 4.00 4.00 2.00 2.00 24h 48h 72h 24h 48h 72h The fourth generation quinolone eyedrops could not prevent from endophthalmitis in a rabbit modelKobayakawa S, Watanabe H, Tsuji A, Tochikubo T.(Toho University, Tokyo, Japan) Methods: Administraion of 0.5%MFLX & 0.3%GFLX (x8, every 15min.). Starting @ 4h and 6h postoperatively. Purpose: To evaluate the in vivo efficacy of gatifloxacin 0.3% and moxifloxacin 0.5% eyedrops in the treatment of Enterococcus faecalis endophthalmitis in a rabbit model. Enucleation of the surgical eye @ 24hr, 48hr and 72hr postoperatively. Examination for the bacterial population. Results: Starting @ 4h postoperatively Starting @ 6h postoperatively No significant differences in those two eyedrops treatment groups Conclusion: We previously reported that a multiple-drop schedule of gatifloxacin produced high aqueous concentrations in a rabbit model. However, multiple administrations for the fourth generation quinolone eyedrops were not efficacy for E. faecalis endophthalmitis in a rabbit model. Kobayakawa S. : cova@med.toho-u.ac.jp