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Heterodimeric Protein Kinases

Heterodimeric Protein Kinases. Presented By: Becky Knight. What makes up a heterodimeric Protein Kinases?. Two different Subunits. Cyclin subunit: regulatory subunit. Increases and decreases during cell cycle. Turns on kinase activity and they are degraded at certain points in cell cycle.

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Heterodimeric Protein Kinases

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  1. Heterodimeric Protein Kinases Presented By: Becky Knight

  2. What makes up a heterodimeric Protein Kinases? Two different Subunits. • Cyclin subunit: regulatory subunit. Increases and decreases during cell cycle. Turns on kinase activity and they are degraded at certain points in cell cycle. • Cyclin-dependant Kinase (Cdk): Catalytic subunit. No activity unless associated with a cyclin.

  3. There are different kinds of Cdks for each phase. • G1 Cdk complex • S-phase Cdk complex • Mitotic Cdk complex

  4. G1 Cdk Complex • Activated by the cell when it is ready to replicate. • Begins breakdown of S-phase inhibitor and prepares cell for s-phase. • Activates the enzymes that are required for gene encoding and DNA replication.

  5. S-phase Cdk Complex • Regulates initiation of DNA replication. • Ensures that the DNA is replicated only once. • It begins to reactivate the s-phase inhibitor.

  6. Mitotic Cdk Complex • Mitosis-promoting Factor (MPF) • Released during the S-phase and G2 phase once DNA is replicated. • Regulates mitosis by activating: the breakdown of nuclear membrane, chromosome condensation, mitotic apparatus assembly, and chromosome alignment. • Activates Anaphase-promoting Complex.

  7. Anaphase-promoting Complex • Activated by MPF complex. • Causes the reverse of mitosis. • Allows for sister chromatid separation and segregation. • Ends mitosis.

  8. Questions???

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