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Supplementary Figure 2

A. HEK293. MRC-5. SKOV-3. MDAH-2774. Igfbp5 mRNA. Gapdh mRNA. anti-IGFBP-5. anti- b -actin. B. mock. IGFBP-5. mock. IGFBP-5. 2000. 1500. anti-CD31 (PECAM-1). tumor volume (mm 2 ). 1000. *. 500. 0. mock. IGFBP-5. 20. 15. number of blood vessels per tumor section. 10.

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Supplementary Figure 2

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  1. A HEK293 MRC-5 SKOV-3 MDAH-2774 Igfbp5 mRNA Gapdh mRNA anti-IGFBP-5 anti-b-actin B mock IGFBP-5 mock IGFBP-5 2000 1500 anti-CD31 (PECAM-1) tumor volume (mm2) 1000 * 500 0 mock IGFBP-5 20 15 number of blood vessels per tumor section 10 * 5 0 mock IGFBP-5 Supplementary Figure 1 Supplementary Figure 2

  2. VEGF untreated IGF-1 (100 ng/ml) Igfbp5 mRNA Gapdh mRNA anti-IGFBP-5 anti-b-actin untreated 10 ng/ml 50 ng/ml 100 ng/ml anti-IGFBP-5 anti-b-actin Supplementary Figure 3 Supplementary Figure 4

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