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Shock. Differential Diagnosis and Hemodynamic Monitoring. By Dr. Ishara Maduka M.B.B.S .(Colombo). Shock is a Cardiovascular Derangement. 1. Deliver Oxygen and Metabolic Substrates 2. Remove Products of Cellular Metabolism 3. Thermoregulation Definition :
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Shock Differential Diagnosis and Hemodynamic Monitoring By Dr. Ishara Maduka M.B.B.S.(Colombo)
Shock is a Cardiovascular Derangement. 1. Deliver Oxygen and Metabolic Substrates 2. Remove Products of Cellular Metabolism 3. Thermoregulation Definition: A physiological state characterized by a significant, systemic reduction in tissue perfusion, resulting in decreased tissue oxygen delivery and insufficient removal of cellular metabolic products, resulting in tissue injury. Shock
Classification of Shock • Hypovolemic • Septic/Inflammatory • Cardiogenic (Intrinsic, compressive & Obstructive) • Neurogenic • Anaphylactic
Brachial systolic blood pressure: <110mmHg • Sinus tachycardia: >90 beats/min • Respiratory rate: <7 or >29 breaths/min • Urine Output: <0.5cc/kg/hr • Metabolic acidemia: [HCO3]<31mEq/L or base deficit>3mEq/L • Hypoxemia: 0-50yr: <90mmHg; 51-70yr: <80mmHg; >71yo<70mmHg; • Cutaneous vasoconstriction vs. vasodilation. • Mental Changes: anxiousness, agitation, indifference, lethargy, obtundation Clinical Markers of Shock
Hypovolemic Shock • Decreased preload->small ventricular end-diastolic volumes -> inadequate cardiac generation of pressure and flow • Causes: • -- bleeding: trauma, GI bleeding, ruptured aneurysms, hemorrhagic pancreatitis • -- protracted vomiting or diarrhea • -- adrenal insufficiency; diabetes insipidus • -- dehydration
Hypovolemic Shock • Signs & Symptoms: Hypotension, Tachycardia, Oliguria, Low volume Pulses. • Markers: monitor UOP,CVP, BP, HR, Hct,CO, lactic acid and PCWP • Treatment: ABCs, IVF (crystalloid), Transfusion Stem ongoing Blood Loss • Patients on β-blockers, w/ spinal shock & athletes may not be tachycardic
Septic/Inflammatory Shock • Mechanism: release of inflammatory mediators leading to • Disruption of the microvascular endothelium • Cutaneous arteriolar dilation and increased capillary permeability • Causes: • Anaphylaxis, drug, toxin reactions • Trauma: crush injuries, major fractures, major burns. • infection/sepsis: G(-/+ ) speticemia,pneumonia, peritonitis, meningitis, cholangitis, pyelonephritis, necrotic tissue, pancreatitis, wet gangrene, toxic shock syndrome, etc.
Septic/Inflammatory Shock Signs: Early– warm peripheries with vasodilatation, often adequate urine output, febrile, tachypnoeic. Late-- vasoconstriction, hypotension, oliguria, altered mental status.
Mechanism: Intrinsic abnormality of heart -> inability to deliver blood into the vasculature with adequate power Cardiogenic Shock • Causes: • Cardiomyopathies: myocardial ischemia, myocardial infarction, cardiomyopathy, myocardiditis, myocardial contusion • Mechanical: cardiac valvular insufficiency, papillary muscle rupture, septal defects, aortic stenosis • Arrythmias: bradyarrythmias (heart block), tachyarrythmias (atrial fibrillation, atrial flutter, ventricular fibrillation) • Obstructive disorders: PE, tension peneumothorax, pericardial tamponade, constrictive pericaditis, severe pulmonary hypertension
Cardiogenic Shock • Characterized by high preload (CVP) with low CO • Signs: Dyspnea, rales, loud P2 gallop, low BP, oliguria
Neurogenic Shock Mechanism: Loss of autonomic innervation of the cardiovascular system (arterioles, venules, small veins, including the heart) • Causes: • Spinal cord injury • Regional anesthesia • Drugs • Neurological disorders
Neurogenic Shock • Characterized by loss of vascular tone & reflexes. • Signs: Hypotension, Bradycardia, Accompanying Neurological deficits.
Monitoring Adjuncts in Shock • Sphyngmomanometry • Pulse Oximeter • Arterial Line • Central Venous Line (Triple Lumen, Pulmonary Artery Catheter)
Questions • List the types of shock. • List the clinical features of shock. • Briefly explain the pathophysiology of each type of shock.