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Seattle Longitudinal Study: Midlife Cognitive Change and Neural Functioning in Aging Adults

This study, led by PIs K. Warner Schaie and Sherry Willis, explores how midlife cognitive changes impact neural and cognitive functioning in old age. The research focuses on memory, executive function, speed, and resource factors affecting cognitive abilities. It examines structural neural changes, risk factors, and biomarkers like MRI shrinkage and white matter integrity using DTI. Factors such as lifestyle, personality, and engagement are considered alongside hippocampal volume and default network activity. This cohort-longitudinal study aims to understand midlife cognitive decline, gain, and stability for better targeted interventions in aging adults. 8

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Seattle Longitudinal Study: Midlife Cognitive Change and Neural Functioning in Aging Adults

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  1. Seattle Longitudinal Study K. Warner Schaie & Sherry Willis (PIs) Collaborators: Elizabeth Aylward Paul Borghesani Kurt Weaver Tara Madhyastha Funding: NIA (R37 AG024102

  2. Seattle Longitudinal Study:A Cohort-Longitudinal Study of Adult Cognition

  3. Midlife Study: Impact of Midlife Cognitive Change on Neural & Cognitive Functioning in Old Age

  4. Midlife Change in Memory Midlife Individual Differences Midlife Normative Change

  5. * Disease * Biomarkers * Lifestyle Risk *Shrinkage (MRI) *White Matter Integrity (DTI) *Cortical Thinning Risk Factors Structural Neural Changes Cognitive Change Decline Gain Stable Abilities: Memory Executive Speed Midlife Cognition Old Age Cognition Functional Neural Changes Resource Factors Default Network Activity • Cognitive Engage • Exercise • Personality

  6. Hippocampal Volume: Midlife Memory Status & Age at Scan

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