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LES HADRONS POUR LA SANTE '

LES HADRONS POUR LA SANTE '. Ugo Amaldi Università di Milano Bicocca e Fondazione TERA. The starting point. 1895 Discovery of X-rays. Wilhelm Conrad Röntgen (1845 – 1923). CT Computer Tomography. target. Linac for the therapy with X-rays. e -  X target. 270  bending magnet.

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LES HADRONS POUR LA SANTE '

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  1. LES HADRONS POUR LA SANTE' Ugo Amaldi Università di Milano Bicocca e Fondazione TERA

  2. The starting point 1895 Discovery of X-rays Wilhelm Conrad Röntgen (1845 – 1923)

  3. CT Computer Tomography

  4. target Linac for the therapy with X-rays e- X target 270 bending magnet Flattening filters 3 GHz Electron linac Ion chambers Multileaf collimator Maximum field size 40  40 cm2 Maximum dose rate: ~ 5 Gy/min

  5. LINAC, multileaf collimator and TPS

  6. 1930 Ernest Lawrence invents the cyclotron M. S. Livingston e E. Lawrence With the 25 inch cyclotron

  7. 1975 450 GeV protons SPS at CERN 1981- SPS is transformed in a proton-antiproton collider Carlo Rubbia and Simon van der Meer

  8. gluon Main results of 30 years of research (1950-1980) Quarks are the constituents of atoms together with electrons They are bound by gluons to form HADRONS

  9. Hadrons penetrating in matter 4500 MeV CARBON (PSI – Villigen)

  10. Comparison of X rays (IMRT) with protons Between eyes In the abdomen In the brain

  11. RBE=Radiobiological Effectiveness In a cell a carbon ion leaves 23 times more energy than a proton The ‘quality’ of the deposited energy is different Carbon ions are effective on “radio-resistant” tumours

  12. Number of potential patients Therapy with X-rays (5 – 20 MeV) 20'000 patients/year in 10 million inhabitants Protontherapy Category A: 1% of X-ray patients = 200 patients/year in 10 M Category B: 10% of X-ray patients = 2'000 patients/year in 10 M Therapy with carbon ions of radioresistant tumours 10% of X-ray patients = 2'000 patients/year in 10 M

  13. NORTHEAST PROTON THERAPY CENTER NPTC of Mas General Hospital Boston (2001) protons ( 235 MeV) cyclotron (IBA) 2 gantries + 2 fixed beams Midwest Proton Radiaton Institute Bloomington (IN) (2003) protons ( 210 MeV) from cyclotron 1 gantry + 1 fixed beam + 1 experimental LOMA LINDA UNIVERSITY CENTER Los Angeles (1992) protons ( 250 MeV) from synchrotron 3 gantries + 2 fixed beams M.D. Anderson Cancer Center Houston (TX) (2004) protons ( 235 MeV) from cyclotron 3 gantries + 1 fixed beam + 1 experimental Hadrontherapy in the world

  14. TSUKUBA CENTRE Ibaraki (2001) protons ( 270 MeV) synchrotron (Hitachi) 2 gantries 2 beam for research WAKASA BAY PROJECT by Wakasa-Bay Energy Research Center Fukui (2002) protons ( 200 MeV) synchrotron (Hitachi) 1 h beam + 1 v beam + 1 gantry KASHIWA CENTER Chiba (1998) protons ( 235 MeV) cyclotron (IBA – SHI) 2 Gantries + 1 hor. beam HYOGO MED CENTRE Hyogo (2001) protons ( 230 MeV) - He and C ions ( 320 MeV/u) Mitsubishi synchrotron 2 p gantries + 2 fixed p beam + 2 ion rooms HEAVY ION MEDICAL ACCELERATOR HIMAC of NIRS (1995) He and C ( 430 MeV/u) 2 synchrotrons 2 h beams + 2 v beams SHIZUOKA FACILITY Shizuoka (2002) protons cyclotron or synchrotron 2 gantries + 1 h beam Hadrontherapy in the world

  15. Hadrontherapy in the world “Hospital-based” centres of protontherapy three in USA two in China one in Korea one in Germany one in Switzerland

  16. Swiss Centre at PSI - Villigen PSI Villigen Optis – eye tratment: 3800 patients PSI “gantry”: 150 patients

  17. PSI: PROSCAN Superconducting cyclotron of ACCEL (Germany)

  18. European projects with carbon ions GSI – Darmstadt Pilot project 200 patients

  19. HICAT - Heidelberg 72,5 Meuro Ready in 2006

  20. TERA PROJECT • A linac IH (GSI) in the ring • Compact lines • Gantries in phase 2 PIMMS (Proton Ion Medical Machine Study) CERN – TERA – Med-Austron Proton Ion Medical Machine Study PIMMS at CERN 1996-2000

  21. Site Announced by Italian Government on 20.1.03 Pavia Close to the University Hospital San Matteo CNAO Foundation: Policlinici di Milano e Pavia, Istituto Neurologico Besta, Istituto Europeo di Oncologia, Istituto dei Tumori, TERA TOTAL: 40,3 Meuro Ready in fall 2007

  22. 5 Pavia Centre CNAO Foundation 4 3 2 1

  23. CNA = Centro Nazionale di Adroterapia for p and 12C Phase 1

  24. Magnets

  25. Prototipo di quadrupolo In collaborazione con i Laboratori di Frascati dell’INFN

  26. General plan Parking lot

  27. Entrata principale ed edificio del sincrotrone STUDIO CALVI s.r.l. Ingegneria e Architettura, Aprile 2003

  28. ENLIGHT EUROPEAN NETWORK ESTRO, EORTC, CERN, GSI Centre of Heidelberg Centre of Pavia Centre of Wiener-Neustadt Centre of Lyon Centre of Stockholm European Network for LIGHt-ion Therapy

  29. 1896-1897 Europa: primi usi dei raggi X in terapia Pavia Heidelberg 2006-2007 Europa: due centri ospedalieri di adroterapia con ioni carbonio

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