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Thyroxine (T 4 )

Thyroxine (T 4 ). By: Jennifer Hahn. Production. Produced in the Thyroid Gland The target cells are all cells of the body It is produced naturally to regulate metabolism During growth spurts more T 4 is produced As a person gets older less T 4 is produced. C 15 H 11 I 4 NO 4.

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Thyroxine (T 4 )

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  1. Thyroxine (T4) By: Jennifer Hahn

  2. Production... • Produced in the Thyroid Gland • The target cells are all cells of the body • It is produced naturally to regulate metabolism • During growth spurts more T4 is produced • As a person gets older less T4 is produced

  3. C15H11I4NO4 Tyrosine derivative

  4. Reaching the Target Cell • Binds to plasma protein • Binds to nucleus • Hormone receptor allows T4 to bind to DNA (to turn on or turn off the gene)

  5. The Facts About Thyroxine • The normal levels of T4 are 4.5-11.2 mcg/dL (micrograms per deciliter) • Hyperthyroidism- overactive thyroid • Hypothyroidism- underactive thyroid • This hormone regulates growth and metabolism for the body • If not enough thyroxine is produced a pure, synthetic form of thyroxine is used as a substitute

  6. Overproduction of Thyroxine • Graves disease- too much T4 speeds up metablosim and stimulate the thyroid uncontrollably. Can lead to liver damage and heart damage if it goes untreated. • Symptoms • Rapid pulse • Tremor (shaking) of the hands • Sweating and • sensitivity to heat • Fatigue • Bulging eyes • Weight loss (despite an increased appetite) • Nervousness, agitation and anxiety • Treatment-Radioactive iodine therapy • Shrinks thyroid gland allowing for less thyroxine to be produced

  7. Underproduction of Thyroxine • Cretinism- The thyroid will produce such little amounts of thyroxine that the thyroid can not function properly. The person’s metabolism and development will be stunted resulting in dwarfism. • Myxedema coma- loss of brain function due to severely low levels of Thyroxine • Symptoms that lead up to myxedema coma: • fatigue • lethargy • mental impairment • depression • cold intolerance • hoarseness • dry skin • weight gain • change in menstrual cycles • constipation • Headaches • Treatment (Cretinism and Myxedema Coma) - Thyroxine is given to patient

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