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Lecture 7: Urogenital System

Lecture 7: Urogenital System. Intermediate Mesoderm Forms Much of the Urogenital System. Paraxial mesoderm (somite). Intermediate mesoderm. Lateral plate mesoderm. Body cavity. Mesoderm in the Chick Embryo. 4.5 weeks. 3 Kidney Systems.

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Lecture 7: Urogenital System

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  1. Lecture 7:Urogenital System

  2. Intermediate Mesoderm Forms Much of the Urogenital System

  3. Paraxial mesoderm (somite) Intermediate mesoderm Lateral plate mesoderm Body cavity Mesoderm in the Chick Embryo

  4. 4.5 weeks 3 Kidney Systems

  5. Urogenital Ridge (red box) 5 Weeks Intermediate Mesoderm Forms the Urogenital Ridge

  6. 5.5 Weeks The Ureteric Bud Forms as an Outgrowth from the Mesonephric Duct

  7. 6-7 Weeks Collecting System Forms from the Ureteric Bud

  8. The Ureteric Bud Induces the Metanephric Blastema to Form Filtration Units

  9. Molecular Regulation of Kidney Development

  10. Kidneys Develop in the Pelvic Region

  11. Ascent of the Kidneys

  12. Ureter Pelvic and Horseshoe Kidneys

  13. Polycystic Kidney Recessive form: 1:5000; cysts from collecting tubules; renal failure in infancy Dominant form: 1:500-1000: cysts from anywhere; renal failure in adulthood

  14. Duplications of the Ureters

  15. Proctodeum 6 Weeks 7 Weeks 8 Weeks Bladder Development

  16. Bladder Development: Incorporation of the Mesonephric Duct

  17. Possible Positions for Ectopic Ureters

  18. Ejaculatory duct Final Position of the Ureters and Mesonephric Duct (Vas Deferens)

  19. Urorectal Septal Defects and Imperforate Anus

  20. Urachal Abnormalities

  21. Cut Line Relationship of the Genital Ridge to the Mesonephric System

  22. 4 Weeks (early) 6 Weeks Migration of the Germ Cells

  23. 6 Weeks Relationship of Germ Cells to the Epithelium of the Genital Ridge

  24. 8 weeks 16 weeks Sertoli cells: derived from epithelium; serve as nurse cells for sperm and produce antimüllerian hormone (AMH; also called müllerian-inhibiting substance [MIS]) Interstitial cells (of Leydig): derived from mesenchyme of genital ridge; secrete testosterone (mesonephric ducts, tubules, etc.; dihydrotestosterone, external genitalia) Formation of the Seminiferous Tubules

  25. 16 Weeks 9 Months Male Tubules and Ducts

  26. 7 Weeks 20 Weeks Formation of Primary Oocytes and Follicular Cells

  27. 9 Months 8 Weeks Derivatives of the Paramesonephric Ducts

  28. Growth of the Urogenital Ridge Produces Fusion between the Paramesonephric Ducts

  29. Formation of the Ovarian Ligaments

  30. 9 Weeks 12 Weeks Newborn Induction of the Vagina by the Paramesonephric Ducts

  31. Vaginal Development

  32. Uterine Abnormalities

  33. Testis and Ovary Development

  34. Genetic Signals: Male vs. Female

  35. 6 Weeks 4 Weeks External Genitalia: Indifferent Stage

  36. 10 Weeks Newborn Penis and Scrotal Development

  37. 8 Weeks Male

  38. 12 Weeks Male

  39. Glandular Hypospadius Urethral and Glandular Hypospadias Hypospadias

  40. Female 11 Weeks

  41. 6 Weeks 5 Months Newborn Female External Genitalia

  42. Female Pseudohermaphrodism (Adrenogenital Syndrome)

  43. Androgen Insensitivity Syndrome (Testicular Feminization)

  44. SRY –SRY, +WNT4 Signals for Sexual Differentiation

  45. 8 Weeks 19 Weeks 28 Weeks Newborn Cryptorchidism: Failure of the testes to reach the scrotal sac (3% of newborns) Descent of the Testes

  46. Layers Covering the Testis

  47. Indirect Inguinal Hernias and Hydroceles

  48. Remnants of the Mesonephric Duct in Females

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